近红外光镊技术结合脂质体膜相变用于硅-金核壳纳米粒子热效应的研究

Study on the Heating Profile of Silica-gold Core/shell Nanoparticles by Near-infrared Optical Tweezers and Lipid Vesicle Phase Transition

通过测定近红外光镊捕获的单个硅-金核壳纳米粒子对荧光标记的脂质体膜加热产生的相变,建立了一种对纳米粒子的激光热效应的三维稳态测定方法。考察了介质温度和激光功率等因素对纳米粒子热效应的影响,并对硅-金核壳纳米粒子和纳米金的光热转换效率进行了比较,结果表明硅-金核壳纳米粒子的光热转换效率最高,其表面温度和光镊激光功率呈正相关(激光功率为0.6 W时,其表面温度达200℃以上)。最后对这类核壳纳米粒子具有良好热效应的原因进行了理论分析。本文建立的方法和获得的结果有助于深入了解硅-金核壳纳米材料的热效应,并展示了这类材料在癌症光热治疗等方面的应用前景。

This study presents a three-dimensional steady-state measurement of heat transduction of a single silica-gold core/shell nanoparticle by trapping it with a near-infrared laser and quantifies the temperature increase by measuring phase transition of a nearby lipid vesicle.Some factors such as the temperature in medium and laser power were investigated to evaluate their influences on the heating effect of the nanoparticles,and the efficiency of photothermal transduction of gold nanoshells and gold nanoparticles were compared.The results show that a gold nanoshell exhibits higher transduction efficiency and its surface temperature shows positive correlation with laser power（the temperature reaches above 200℃at0.6 Wlaser power）.Finally,the excellent photothermal property of gold nanoshells is explained theoretically.The assay in this study is beneficial for a deep understanding of heating effect of silica-gold nanosells and shows agreat promise of this material in photothermal therapy of cancers,etc.