某中医院多重耐药菌感染的流行特征及耐药性分析

Analysis on Drug Tolerance and Epidemic Features of Multi-drug Resistant Organisms Infection in a TCM Hospital

目的:了解医院多药耐药菌(MDRO)感染的流行特征及耐药状况,为医院感染防控工作提供基础数据。方法:调查并分析2009年6月至2012年12月某中医院检出多重耐药菌住院患者的特点和耐药趋势。结果:共调查多重耐药菌感染患者719例次,检出耐药菌799株,最常见的多重耐药菌为大肠埃希菌(28.85%)、鲍曼不动杆菌(12.66%)、铜绿假单胞菌(8.62%)、金黄色葡萄球菌(7.70%)、肺炎克雷伯菌(7.44%)、表皮葡萄球菌(7.31%);MDRO常见的感染部位为呼吸系统(32.68%)、手术部位(24.20%)、泌尿系统(20.72%);大肠埃希菌和肺炎克雷伯对亚胺培南和美罗培南敏感外,对其他抗菌药物均耐药,鲍曼不动杆菌和铜绿假单胞菌对米诺环素和多黏菌素B敏感外,对其他抗菌药物均耐药,金黄色葡萄球菌和表皮葡萄球菌对万古霉素有较高的敏感性。结论:医疗机构应加强多重耐药菌感染的防控工作,临床医师应依据药敏试验结果合理使用抗生素,减少医院感染的发生。

Objective： To provide basic data for the prevention and control of hospital infection by investigating epidemic features and drug tolerance of multi-drug resistance organisms （MDRO）. Methods： The inpatients with MDRO were detected from June, 2009 to December, 2012, the features and drug tolerance trend were analyzed. Results： All 719 cases of MDRO patients were investigated, there were 799 strains of drug-tolerance bacteria, the common MDROs were Escherichia coli （E.coli 28.85%）, Baumanii （12.66%）, Pseudomonas aeruginosa （8.62%）, Staphylococcus aureus （7.70%）, Klebsiella pneumoniae （7.44%） and Staphylococcus epidermidis （7.31%）; Common infected areas of MDRO were respiratory system （32.68%）, surgical site （24.20%） and urinary system （20.72%）; E.coli and Klebsiella pneumoniae were resistant to other antibacterial drugs except sensitive to imipenem and meropenem, Baumanii and Pseudomonas aeruginosa were resistant to other antibacterial drugs except sensitive to minocycline and polymyxin B, Staphylococcus aureus and Staphylococcus epidermidis were sensitive to Vancomycin. Conclu- sion： Medical institutions should enhance the prevention and the control of MDRO infection, the doctor should use antibacterial drugs rationally according to the results of drug sensitive tests to reduce the incidence of hospital infection.