盐酸川芎嗪注射液联合西比灵胶囊治疗后循环缺血82例

Treatment for 82 Cases of Posterior Circulation Ischemia by Ligustrazine Hydrochloride Injection Combined with Sibelium Capsule

目的:观察盐酸川芎嗪注射液联合西比灵胶囊治疗后循环缺血的临床疗效。方法:将162例后循环缺血患者随机分为治疗组82例和对照组80例。在常规治疗的基础上,治疗组予以静滴盐酸川芎嗪注射液+口服西比灵胶囊,对照组予口服西比灵胶囊,观察治疗效果及椎动脉和基底动脉血流速度的改善情况。结果:总有效率治疗组为97.6%,对照组为77.5%,2组比较差异显著(P<0.05)。治疗组椎动脉、基底动脉血流速度改善与对照组相比有明显差异(P<0.05)。结论:盐酸川芎嗪注射液联合西比灵胶囊治疗后循环缺血疗效优于单用西比灵胶囊。

Objective：To observe clinical effects of ligustrazine hydrochloride injection and sibelium capsules in treating posterior circulation ischemia （PCI）. Methods：All 162 PCI patients were randomized into 82 cases of the treatment group and 80 cases of the control group. On the foundation of routine treatment, the treatment group re-ceived intranvenous dripping of ligustrazine hydrochloride injection and oral administration of sibelium capsules, the control group took sibelium capsules orally, curative effects of both groups were observed, the improvements of blood flow rates of vertebral artery and vertebra basilar artery were measured by TCD. Results：Total effective rate of the treatment group was 97.6%, higher than 77.5%of the control group with significant difference （P〈0.05）. The comparison between the treatment group and the control group had significant difference in improving blood flow rates of vertebral artery and vertebra basilar artery （P〈0.05）. Conclusion：Ligustrazine hydrochloride injection and sibelium capsules in treating PCI are superior to sibelium capsules only.