雷替曲塞和奥沙利铂同步放射治疗对中晚期食管癌患者生活质量的影响

Effect of raltitrexed plus oxaliplatin combined with concurrent radiotherapy on life quality of advanced esophageal carcinoma

目的评价应用雷替曲塞和奥沙利铂同步放疗对中晚期食管癌患者生活质量的影响。方法应用食管癌专用评分量表(QLQ-OES18)对54例接受雷替曲塞和奥沙利铂同步放射治疗的食管癌患者分别于治疗前1d(基线状态)、治疗结束后1d、治疗结束后1个月评价生活质量。比较各条目在治疗不同时间点的评分差异,并将治疗后1个月与基线状态评分差与近期疗效行相关分析。结果治疗结束后1d,吞咽困难、进食困难、咽口水评分较基线状态显著降低(P<0.05),进食疼痛评分较基线状态显著增加(P<0.05),其余条目差异无统计学意义(P>0.05);治疗后1个月评分除了反流和言语外,其余条目均较基线状态水平显著降低(P<0.05)。吞咽困难、进食困难、吞咽梗阻及进食疼痛在治疗后1个月评分较基线状态的改善情况与近期疗效呈显著正相关,相关系数分别为0.85、0.55、0.73、0.32(P<0.05)。结论雷替曲塞和奥沙利铂同步放射治疗对中晚期食管癌患者的生活质量有一过性影响,但多数症状在治疗结束后1个月明显改善。

Objective To evaluate the effect of raltitrexed plus oxaliplatin combined with concurrent radiotherapy on life quality of advanced esophageal carcinoma.Methods Oesophageal cancer specific health related quality of life questionnaire（QLQ-OES18） was used to evaluate the life quality of 54 patients with esophageal carcinoma respectively at 1 day pre-treatment（baseline level）,1 day post-treatment and 1month post-treatment.Total 54 patients were treated with raltitrexed plus oxaliplatin combined with con-current radiotherapy.Comparing the differences of quality of life scores at different time points,and analyzing the correlation of the differences between the 1month post-treatment and baseline score and short term effect.Results The scores of difficulty swallo-wing,eating difficulties,saliva decreased significantly at 1 day post-treatment than that of pre-treatment（P〈0.05）,the scores of eating pain increased significantly at 1 day post-treatment than that of pre-treatment（P〈0.05）and there was no significantly differ-ences in other items（P〉0.05）.The scores of 1 day post-treatment were significantly reduced compared to baseline levels except re-flux and speech（P〈0.05）.It was positive correlation between the difference of 1 month post-treatment and baseline score and short term effect,and the correlation coefficients was 0.85,0.55,0.73,0.32（P〈0.05）,respectively.Conclusion There is a transient im-pact of raltitrexed plus oxaliplatin combined with concurrent radiotherapy on quality of life for advanced esophageal carcinoma after treatment,but most of the life quality of the patients could be improved after 1 month obviously.