大肠癌组织中膜联蛋白A1的表达及其病理意义

Expression of annexin A1 in tissues of colorectal carcinoma and its clinical pathological significance

目的研究膜联蛋白A1(Annexin A1)在大肠癌组织中的表达及其与大肠癌临床病理特征之间的关系。方法选取48例患者大肠癌组织、36例患者癌旁组织、15例患者腺瘤性息肉组织手术切除标本,采用免疫组织化学法检测各组织中Annexin A1的表达水平。结果大肠癌组织中Annexin A1的阳性表达率(64.6%)高于癌旁组织(38.8%)、腺瘤性息肉组织(40.0%),差异有统计学意义(P<0.05)。Annexin A1阳性表达的癌旁组织、腺瘤性息肉组织均呈轻至重度不典型增生。高分化腺癌、肿瘤最大径小于5cm、淋巴结未转移及未侵犯周围组织的大肠癌患者Annexin A1的阳性表达率均明显低于中或低分化腺癌、肿瘤最大径大于或等于5cm、有淋巴结转移及侵犯周围组织者(P<0.05)。结论 Annexin A1的表达水平可能是反映大肠癌发生、发展及生物学行为的重要指标。

Objective To investigate the expression of Annexin A1 proteins in colorectal cancer tissues and the relationship be-tween it and clinicopathologic features of colorectal cancer.Methods The surgical specimens from 48 cases of colorectal cancer,36 cases of adjacent tissues,15 cases of adenoma polyp were used to be examined expression of Annexin A1 immunohistochemical method.Results The positive expression rate of Annexin A1 in cancer tissue（64.6%）was significantly higher than those in adja-cent tissues（38.8%）and adenoma polyp tissues（40.0%）（P〈0.05）.The adjacent tissues and adenoma polyp tissues with positive Annexin A1 expression showed mild to severe atypical hyperplasia.The positive rates of Annexin A1 were significantly lower in the well-differentiated adenocarcinoma,tumor size of 〈5 cm,with no metastasis to lymphnodes and no invasion to surrounding tissues of colorectal cancer than those in the moderately or poorly differentiated adenocarcinoma,tumor size of ≥5 cm,with metastasis to lymphnodes and invasion in surrounding tissues（P〈0.05）.Conclusion The expression levels of Annexin A1 may be an important index of occurrence,progression and biological behaviors of colorectal carcinoma.