鼻内糖皮质激素对鼻息肉组织中EGF和EGFR表达的影响

Effects of intranasal glucocorticoid on the expression of EGF and EGFR in nasal polyps

目的探讨鼻内应用糖皮质激素对鼻息肉组织中表皮细胞生长因子(EGF)和表皮细胞生长因子受体(EGFR)表达的影响。方法鼻息肉患者42例,随机分为激素组(布地奈德鼻喷雾剂128μg/次,2次/d,疗程12周)和对照组(生理盐水喷鼻,2次/d,疗程12周),每组21例,采用鼻息肉内镜评分评估鼻息肉治疗效果,同时采用免疫组织化学染色方法检测两组鼻息肉组织中EGF和EGFR的表达情况。结果与对照组比较,激素组鼻息肉内镜评分下降(P<0.05),黏膜上皮细胞EGF[(0.15±0.04)vs(0.24±0.06)]的表达减少(P<0.05),EGFR的表达无差异无统计学意义(P>0.05)。结论糖皮质激素能抑制鼻息肉黏膜上皮细胞EGF的表达,对EGFR的表达无影响,这可能是其治疗鼻息肉的作用机制之一。

Objective To explore the effects of intranasal glucocorticoid on the expression of epidermal growth factor （EGF） and epidermal growth factor receptor （EGFR） in nasal polyps. Methods Forty-two patients with nasal polyps were equally randomized divided into two groups：group A （n=21, treated with budesonide 128μg, BID, 12 weeks） and group B （n=21, normal saline, BID, 12 weeks）. The expression of EGF and EGFR in nasal polyps were detected with immunohistochemistry and the therapeutic effect of nasal polyps were evaluated with the nasal en-doscopic score system. Results The expression of EGF in the epithelial cells [（0.15±0.04） vs （0.24±0.06）] and endo-scopic staging of nasal polyps were significantly lower in group A than that in group B （P〈0.05）. The expression of EGFR in group B did not differ significantly from group A （P〉0.05）. Conclusion Inhibiting the expression of EGF and not EGFR in the epithelial cells of nasal polyps may be one of mechanisms for the therapeutic effect of intranasal glucocorticoid on the nasal polyps.