番禺区体检人群血清尿酸水平及相关危险因素分析

Analysis of the serum uric acid level in general population of Panyu district and relavant risk factors

目的了解本地区人群血清尿酸(UA)水平及其相关危险因素。方法收集15 632例体检人群的血尿酸(UA)、尿素(Urea)、肌酐(Crea)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等8项生化指标,并分析UA水平和高尿酸血症(HUA)的危险因素。结果体检人群HUA的患病率为36.24%(5 665/15 632),男性HUA患病率是女性的2.2倍。UA水平、HUA患病率在不同性别、年龄之间差异有统计学意义(P<0.05)。UA水平、HUA患病率随年龄增长呈"J"形曲线变化。Pearson相关分析结果显示,UA水平与年龄、FPG、TC、TG、LDL-C、Urea和Crea呈正相关(P均<0.01),与HDL-C、性别呈负相关(P均<0.01);多元线性回归分析结果显示,FPG、HDL-C和女性是HUA的保护因素,TG、LDL-C、Urea和Crea是HUA水平的危险因素;多因素Logistic回归分析结果显示,FPG、TC和HDL-C是HUA的保护因素,性别、TG、LDL-C、Urea和Crea是HUA的危险因素。结论总体检人群UA水平随年龄增长呈"J"形曲线变化。TC、TG、LDL-C、Urea和Crea是HUA的危险因素,而HDL-C、女性是HUA的保护因素。

Objective To explore the serum uric acid （UA） level distribution and relevant risk factors in gener-al population of Panyu district. Methods Eighty biochemical indicators including UA, urea （Urea）, creatinine （Crea）, fasting plasma glucose （FPG）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL-C）, low density li-poprotein （LDL-C） were collected from 15 632 local residents. And risk factors of UA level and hyperuricemia （HUA） prevalence rate were analysed. Results The HUA prevalence rate was 36.24%（5 665/15 632）, and that HUA preva-lence rate of males was 2.2 times than that of females. The differences of UA level and HUA prevalence rate between genders and ages were statistically significant （P〈0.05）. The UA level and HUA prevalence rate showed a“J”curve rela-tionship with aging. The Pearson correlation analysis showed that UA level was positively correlated with age, FPG, TC, TG, LDL-C, Urea and Crea, while negatively correlated with HDL-C and female gender. Multiple linear regression anal-ysis showed that TG, LDL-C, Urea and Crea were risk factors, while FPG, HDL-C and female gender were the protec-tive factors of HUA;And multiple Logistic regression analysis showed that gender, TG, LDL-C, Urea and Crea were risk factors, while FPG, TC and HDL-C were the protective factors of HUA. Conclusion The Serum UA level in gen-eral population showed a“J”curve relationship with aging. TC, TG, LDL-C, Urea and Crea are risk factors of HUA, while female gender and HDL-C are the protective factors.