马兜铃酸Ⅰ致癌作用及其与代谢酶关系的研究进展

Progress in Aristolochic Acid Carcinogenesis and Its Related Metabolic Enzymes

马兜铃酸(aristolochic acid,AA)广泛存在于马兜铃科马兜铃属中草药中,是马兜铃酸肾病(aristolochic acid nephropathy,AAN)的致病因素,此类肾病患者可伴发泌尿系统肿瘤,阐明马兜铃酸的致癌机制成为其毒性研究的一大焦点。马兜铃酸Ⅰ(AAⅠ)是马兜铃酸的主要毒性成分,其在体内经氧化还原后活化,与DNA共价结合形成加合物而诱发癌变。本文综述参与AAⅠ氧化还原的代谢酶及其代谢过程在AAⅠ致癌中的作用。

Aristolochic acid（AA）,a major active component of Aristolochiaceae Aristolochia herbs,is the pathogenic factor of aristolochic acid nephropathy（AAN）. And AAN patients were usually complicated by urinary cancer.Therefore,the study on the carcinogenesis mechanisms of AA has become the focus in its toxicity research. Recently,researches have demonstrated that aristolochic acidⅠ（AAⅠ）was the main toxic component of AA,and was activated following the oxidation-reduction process. After activation, AA Ⅰ can induce carcinoma through forming AA Ⅰ-DNA adducts. This review summarizes the latest research of the enzymes participating in AAⅠ metabolism and their roles in the progress of AA carcinogenesis,which may provide references for follow-up research and its clinical application.