复合型可注射磷酸钙骨水泥应用于胫骨平台SchatzkerⅡ型骨折的生物力学研究

Biomechanical study on composite type injectable calcium phosphate bone cement in Type Ⅱ Schatzker tibial plateau fractures

目的研究复合型可注射磷酸钙骨水泥应用于胫骨平台SchatzkerⅡ型骨折的生物力学效果。方法选取10对老年尸体胫骨近端标本,制备成胫骨平台SchatzkerⅡ型骨折模型;将10对标本随机分配到观察组和对照组,分别采用复合型可注射磷酸钙骨水泥和自体松质骨进行植骨固定,检测两组标本的生物相容性以及生物力学强度。结果观察组复合型可注射磷酸钙骨水泥料浸提液处理后,小鼠结缔组织成纤维细胞株L929的MTT值以及G0/G1比例、S期比例、G2/M期比例与对照组自体松质骨浸提液处理无差异;观察组标本的最大载荷及抗压刚度值均高于对照组。结论复合型可注射磷酸钙骨水泥的最大载荷以及抗压刚度均更大,且与自体松质骨的生物相容性相当,是治疗胫骨平台SchatzkerⅡ型骨折的理想材料。

Objective To study the biomechanical effects of composite type injectable calcium phosphate bone cement in Type Ⅱ Schatzker tibial plateau fractures. Methods Ten couples of elderly cadavers（mice） proximal tibia specimens were collected and prepared for Schatzker Ⅱ tibial plateau fracture model; 10 couples of specimens were randomly divided into observation group and control group, given respectively composite type injectable calcium phosphate bone cement and autogenous cancellous bone for bone grafting fixation. Biocompatibility and biomechanics of the two groups were compared. Results After the composite type injectable calcium phosphate bone cement extract liquor treatment in observation group, the MTT value and G0/G1 ratio, S ratio, G2/M ratio of connective tissue fibroblast cell line L929 had no difference with that of the control group; but the maximum load and compression stiffness values of observation group were higher than those of the control group. Conclusion The maximum load and compression stiffness values of composite type injectable calcium phosphate bone cement are larger, and its biocompatibility is equal with that of the autogenous cancellous bone. It is thus an ideal material for Type Ⅱ Schatzker tibial plateau fractures.