毛发红糠疹病因及发病机制的研究进展

Research progress of etiology and pathogenesis in pityriasis rubra pilaris

毛发红糠疹是一种少见的慢性鳞屑性角化性炎症性皮肤病,以黄红色鳞屑性斑片和角化性毛囊性丘疹为特征。尽管毛发红糠疹确切的病因和发病机制还不明确,但近几年的研究表明遗传因素、角化障碍、维生素缺乏、肿瘤、感染、药物等与其发病关系密切。

Pityriasis rubra pilaris is a rare chronic inflammatory keratosis, which is clinically characterized by gradually developing reddish or orange extending plaques and keratotic follicular papules. Although the exact etiology and pathogenesis mechanisms in Pityriasis rubra pilaris are unclear, recently, studies have shown that genetic factors,keratinization disorders, vitamin deficiencies, cancer, infections, drugs, are closely related to its onset.