脑卒中后疲劳患者血清白介素-1β水平变化及早期护理干预效果研究

Changes of Serum Interleukin- 1β Level in Patients with Post Stroke Fatigue and Effect of Early Nursing Intervention

目的探讨脑卒中后疲劳(PSF)患者血清白介素-1β(IL-1β)水平变化及早期护理干预效果,为PSF的防治提供参考。方法选取2013年12月—2014年6月我院收治的缺血性脑卒中患者105例,随机分为对照组52例和干预组53例。对照组患者实施常规治疗和护理,干预组患者在对照组基础上实施早期护理干预。干预2周后,采用疲劳严重度量表(FSS)判断所有患者是否发生PSF,并检测其血糖、糖化血红蛋白(Hb A1c)、IL-1β、HDLC、LDL-C、TC及TG。结果干预组患者FSS总分为(2.9±1.5)分,低于对照组的(3.8±1.7)分(P<0.05)。干预组13例患者发生PSF(干预-PSF组),40例患者未发生PSF(干预-非PSF组);对照组23例患者发生PSF(对照-PSF组),29例患者未发生PSF(对照-PSF组)。干预-PSF组血糖、Hb A1c、IL-1β、HDL-C高于对照-PSF组和干预-非PSF组,对照-PSF组血糖、Hb A1c、IL-1β、HDL-C高于对照-非PSF组(P<0.05)。结论PSF患者血清IL-1β水平明显升高,IL-1β在PSF的发生和发展过程中发挥着重要作用;早期护理干预有助于减少PSF的发生,延缓PSF的发展。

Objective To investigate the changes of serum interleukin -1β（ IL-1β） level in patients with post stroke fatigue （ PSF） and effect of early nursing intervention , to provide references for prevention and treatment .Methods From December 2013 to June 2014, 105 patients with ischemic stroke were selected in our hospital , and they were randomly di-vided into control group （n=52） and intervention group （n=53） .Control group given routine treatment and nursing , while intervention group given early nursing intervention based on routine treatment and nursing.After 2 weeks of intervention , fatigue severity scale （FSS） was used to judge PSF, and blood glucose, HbA1c, IL-1β, HDL-C, LDL-C, TC, TG were detec-ted.Results The total score of FSS of intervention group was （2.9 ±1.5）, was lower than that of control group of （3.8 ± 1.7） （P〈0.05） .In the intervention group, 13 cases occurred PSF （intervention-PSF group）, 40 cases did not （interven-tion-non PSF group ）; in the control group , 13 cases occurred PSF （ control-PSF group ） , 29 cases did not （ control -non PSF group） .Blood glucose, HbA1c, IL-1β, HDL-C of intervention -PSF group were higher than those of control -PSF group and intervention-non PSF group , and those of control -PSF group were higher than those of control -non PSF group （ P〈0.05）.Conclusion Serum IL-1βlevel is higher in patients with PSF , which plays a important role in the onset and devel-opment of PSF , and early nursing intervention is helpful to reduce and postpone PSF .