丙型肝炎病毒核心抗原诊断价值的研究

Evaluation on Core Antigen in Diagnosis of Hepatitis C Virus

目的探讨慢性丙型肝炎病毒核心抗原（HCV-c Ag）定量与患者病毒载量、丙型肝炎病毒抗体（HCV-Ab）、丙氨酸氨基转移酶（ALT）的相关性。方法检测88例慢性丙型肝炎患者血清HCV-c Ag、HCV-Ab、ALT及HCV RNA,并进行对比分析。结果 88例慢性丙型肝炎患者中,HCV RNA阳性率为64.8%（57/88）,HCV-c Ag阳性率51.1%（45/88）。随HCV RNA浓度降低,HCV-c Ag阳性率逐渐下降（P〈0.05）,HCV-c Ag浓度逐渐降低（P〈0.05）。HCV-Ab阳性率为92.0%（81/88）,HCV-Ab阳性组HCV-c Ag浓度显著高于HCV-Ab阴性组（P〈0.05）。丙型肝炎患者HCV-c Ag浓度与HCV-Ab浓度呈正相关关系（P〈0.05）。ALT浓度151～250 U/L者25例（28.4%）,61～150 U/L者29例（33.0%）,≤60 U/L者34例（38.6%）。3组HCV-c Ag浓度比较,差异无统计学意义（P〉0.05）。结论 HCV-c Ag可作为慢性丙型肝炎患者辅助诊断的指标之一。

Objective To investigate the correlation of chronic hepatitis C virus core antigen（ HCV-c Ag）quantitative detection with viral load,hepatitis C virus antibody（ HCV-Ab） and ALT. Methods The serum samples of88 patients with chronic hepatitis C were collected to detect the HCV-c Ag,HCV-Ab,ALT and HCV RNA levels,and a comparative analysis was conducted. Results Among 88 patients with chronic hepatitis C,the positive rate of HCV RNA was 64. 8%（ 57 /88）,and the positive rate of HCV-c Ag was 51. 1%（ 45 /88）. The positive rate and concentration of HCV-c Ag decreased gradually with the decreasing HCV RNA concentration（ P〈0. 05）. The positive rate of HCV-Ab was92. 0%（ 81 /88）. The HCV-c Ag concentration in the positive HCV-Ab group was significant higher than that in the negative HCV-Ab group（ P〈0. 05）. The HCV-c Ag concentration positively correlated with the HCV-Ab concentration among hepatitis C patients（ P〈0. 05）. The patients with the ALT concentration of 151- 250 U / L accounted for28. 4%（ 25 cases）,of 61- 150 U / L 33. 0%（ 29 cases）,≤60 U / L 38. 6%（ 34 cases）. There was no significant difference in the HCV-c Ag concentration among three groups（ P〈0. 05）. Conclusion HCV-c Ag can be used as one of the indicators for the auxiliary diagnosis of chronic hepatitis C.