阿维A胶囊对寻常型银屑病患者外周血I-TAC表达的影响被引量：2

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摘要目的观察阿维A胶囊对寻常型银屑病患者外周血T细胞α化学趋化因子(I-TAC)表达的影响。方法中重度寻常型银屑病患者60例,按随机数字表法分为两组,每组30例。对照组局部外涂雅漾三重修护霜、口服甲氨蝶呤;研究组在对照组基础上口服阿维A胶囊0.5 mg/(kg·d),疗程为8周。采用夹心酶联免疫吸附法检测治疗前后的外周血I-TAC水平。结果治疗前两组患者PASI评分、I-TAC水平比较差异无统计学意义(P>0.05),治疗后均显著低于治疗前(P<0.05),且研究组显著低于对照组(P<0.05)。研究组有效率为86.67%(26/30),高于对照组的53.33%(16/30)(P<0.05)。结论阿维A胶囊可以降低寻常型银屑病患者血清I-TAC水平,I-TAC可能在银屑病的病程进展中发挥重要作用。

作者樊卓覃静净王丹丹党云

机构地区西安医学院附属医院皮肤科

出处《广西医学》 CAS 2014年第11期1622-1624,共3页 Guangxi Medical Journal

基金陕西省教育厅专项科研计划项目(12JK0780)

关键词银屑病阿维A胶囊 T细胞α化学趋化因子

分类号 R458.63 [医药卫生—治疗学]

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