阿维A胶囊对寻常型银屑病患者外周血I-TAC表达的影响被引量：2

下载PDF

导出

摘要目的观察阿维A胶囊对寻常型银屑病患者外周血T细胞α化学趋化因子(I-TAC)表达的影响。方法中重度寻常型银屑病患者60例,按随机数字表法分为两组,每组30例。对照组局部外涂雅漾三重修护霜、口服甲氨蝶呤;研究组在对照组基础上口服阿维A胶囊0.5 mg/(kg·d),疗程为8周。采用夹心酶联免疫吸附法检测治疗前后的外周血I-TAC水平。结果治疗前两组患者PASI评分、I-TAC水平比较差异无统计学意义(P>0.05),治疗后均显著低于治疗前(P<0.05),且研究组显著低于对照组(P<0.05)。研究组有效率为86.67%(26/30),高于对照组的53.33%(16/30)(P<0.05)。结论阿维A胶囊可以降低寻常型银屑病患者血清I-TAC水平,I-TAC可能在银屑病的病程进展中发挥重要作用。

作者樊卓覃静净王丹丹党云

机构地区西安医学院附属医院皮肤科

出处《广西医学》 CAS 2014年第11期1622-1624,共3页 Guangxi Medical Journal

基金陕西省教育厅专项科研计划项目(12JK0780)

关键词银屑病阿维A胶囊 T细胞α化学趋化因子

分类号 R458.63 [医药卫生—治疗学]

引文网络
相关文献

参考文献13

1Albanesi C, De Pita O, Girolomoni G. Resident skin cells in psoriasis : a special look at the pathogenetic functions of ke- ratinocytes[ J]. Clin Dermatol,2007,25(6) :581 -588.
2Wolfram JA, Diaconu D, Hatala DA, et al. Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis [ J ]. Am J Pathol, 2009,174 (4) ,1 443 -1 458.
3吴剑,肖汀,王志华,吴严,何春涤,高兴华,陈洪铎.银屑病皮损中CXCL11/I-TAC及其受体CXCR3的表达[J].中国免疫学杂志,2009,25(5):462-463. 被引量：4
4史玉玲,顾俊瑛,徐晓光,毕新岭,王英,郭志丽,顾军.阿维A对中、重度斑块状银屑病患者Th17细胞相关因子的影响[J].中国皮肤性病学杂志,2011,25(1):21-23. 被引量：22
5无,郑志忠(执笔).中国银屑病治疗指南（2008版）[J].中华皮肤科杂志,2009,42(3):213-214. 被引量：194
6陈永锋,常树霞,郑道城.寻常性银屑病患者外周血和皮损中Th17细胞及相关因子的表达[J].中华皮肤科杂志,2011,44(1):11-14. 被引量：31
7Cole KE, Strick CA, Paradis TJ, et al. Interferon-inducible T cell alpha chemoattractant(I-TAC) :a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 [J].J Exp Med, 1998,187(12) :2 009 -2 021.
8Tensen CP, Flier J, Van Der Raaij-Helmer EM, et al. Hu- man IP-9:A keratinocyte-derived high affinity CXC-chemo- kine ligand for the IP-10/Mig receptor(CXCR3) [ J]. J In- vest Dermatol, 1999,112 (5) :716 - 722.
9Flier J, Boorsma DM, van Beek PJ, et al. Differential ex- pression of CXCR3 targeting chemokines CXCL10, CXCLg, and CXCL11 in different types of skin inflammation [ J ]. J Patho1,2001,194 (4) : 398 - 405.
10Hermann C, Assmus B, Urbich C, et al. Insulin-mediated stimulation of protein kinase Akt: A potent survival signa- ling cascade for endothelial ceils [ J ]. Arterioscler Thromb Vasc Biol,2000,20(2) :402 -409.

二级参考文献46

1黄琨,刘厚君,涂亚庭.寻常型银屑病患者皮损中白介素-22和S100A7,A8,A9mRNA的表达及关系[J].中国皮肤性病学杂志,2007,21(3):138-140. 被引量：9
2Cole K E, Strick C A, Paradis T Jet al. Interferon-inducible T cell alpha chemoattractant (I-TAC):a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CX- CR3 [J]. J Exp Med, 1998; 187(12) :2009-2021.
3Tensen C P, Flier J, Vander raajj-helmer E Met al. Human IP-9: a keratinocyte-defived high affinity CXC chemokine ligand for the IP-10/MIG receptor (CXCR3) [J] .J Invest Dermatol, 1999; 112(5) :716-722.
4Flier J, Boorsma D M, van Beek P Jet al. Differential expression of CX- CR3 targeting chemokines CXCL10, CXCL9, and CXCLll in different types of skin inflammation[J] .J Pathol,2001 ; 194 (4) :398--405.
5Austin L M, Ozawa M, Kikuchi T et al. The majority of epidermal T cells in psoriasis vulgaris lesions can produce type I cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytoxic T lymphocyte) and Th1 effector populations: a type 1 differentiation bias isalso measured in circulating blood T cells in psoriatic patients [J] .J Invest Dermatol, 1999; 113 (5) :752-759.
6Khan A, Farah C S, Savage N W etal. Th1 cytokines in oral lichen planus. [J] .J Oral Pathol Med,2003;32(2) :77-83.
7Albanesi C, Scarponi C, Sebastiani Set al. IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines [ J ]. J Immunol, 2000 ; 165 (3) : 1395-1402.
8Xiao T, Kagami S, Saeki H etal. Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line, HaCaT ceils [ J ]. J Dermatol Sci, 2003 ; 31 (2) : 111-117.
9Konur A, Schulz U, Eissner Get al. Interferon (IFN)-γ is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-y and tumor necrosis factor-a production[J]. Br J Dermatol,2005; 152(6) : 1134-1142.
10Tesmer LA,Lundy SK,Sarkar S,et al.Th17 cells in human disease.Immunol Rev,2008,223:87-113.