天然药物化学成分的生物转化研究进展

Natural Medicine Chemistry Biotransformation is Reviewed

目的:天然药物的化学成分是天然药物研究及天然药物发挥疗效的基础,很难采用常规化学法进行合成或结构改造得到具有新颖活性的化合物,因此采用生物转化的方法对其化学结构进行修饰。文章对天然药物化学成分及其生物转化的研究进展进行概括介绍。方法:查阅国内外及校图书数据库相关文献,以常见天然药物化学成分为基础,将近年来生物转化技术用于如苷类,萜类及生物碱等研究情况进行归纳、总结、评述。结果:国内外学者对天然药物中某种单一有效成分的转化研究较为深入,得到了一些新化合物,其中部分新化合物的活性甚至超过了转化母体。结论:用生物转化的方法处理天然药物,将其用于复杂活性成分的筛选和研制,并与高效快速的药物筛选手段相结合,是发掘天然高活性低毒先导化合物的重要途径。

the chemical composition of natural medicine is the natural medicine study and curative effect of natural medicine; it is difficult to adopt routine method for synthesis and structure modification with novel active compounds, so adopt the method of biological transformation by modifying the chemical structure. Methods： the correlative literature at home and abroad and the school books database, on the basis of common natural medicine chemistry, biological transtbrmation technology over the years for such as glycosides, terpenoids, alkaloids, etc., summarized the research situation, summarized and reviewed. Results： the scholars at home and abroad of a single active ingredient in natural medicine translational research more in-depth, got some new compounds, the activity of some of these new compounds, even more than the transformation matrix. Conclusion： use the method of bioconversion processing natural medicines, be used to complex filter and the development of active ingredients, and combined with efficient and rapid drug screening method, is an important approach to explore natural highly active low toxicity of lead compounds.