摘要
抗性基因作为一类严重威胁人类健康和生命安全的新型环境污染物,近年来引起了广泛的关注.四环素类抗性基因是环境和临床上研究得最多的一大类抗性基因,目前已报道的相关基因共有44种,包含泵出、核糖体保护和酶修饰3种主要机制.相对于前两种机制,酶修饰机制关注得不多.tet(X)是唯一一种研究较为透彻的酶修饰基因,它编码的蛋白可化学修饰和降解四环素,广泛存在于各种环境介质中,对临床耐药性的发展具有一定的贡献.本文综述了tet(X)基因的研究进展,指出有必要重新认识tet(X)对环境中四环素类生物降解的贡献及其对于细菌四环素耐药性发展的重要性,并对tet(X)的未来研究方向进行了展望.
The mass production and use of tetracycline antibiotics accelerate the development of tetracycline resistance genes（ TRGs）,which shade health risks to humans and animals. Among the known 44 TRGs,tet（ X）,one of the two enzymatic modification genes,was found to be widely present in various environmental media,and has certain contribution to the antibiotic resistance of clinical isolates in recent years. However,this gene received little attention. This article reviews the research advances of tet（ X） gene,including its degradation mechanism for TCs,environmental distribution and potential utilization in biodegradation and risk control. The prospects on the research of tet（ X） are also presented.
出处
《环境化学》
CAS
CSCD
北大核心
2014年第12期2027-2037,共11页
Environmental Chemistry
基金
国家自然科学基金项目(21277162)
科技部中日合作课题(2013DFG50150)资助
关键词
四环素类抗生素
四环素抗性基因
tet(X)
酶修饰
降解
tetracycline antibiotics
tetracycline resistance genes
tet（X）
enzymatic modification
biodegradation
