两种方法治疗妊娠期肝内胆汁淤积症的疗效比较

Comparison of two methods in the treatment of intra hepatic cholestasis during pregnancy

目的比较妊娠期肝内胆汁淤积症(ICP)不同治疗方法的疗效。方法对我院2010年1月至2014年5月住院的125例ICP患者进行前瞻性研究,统计皮肤瘙痒评分、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、血总胆汁酸的改善、围生儿病死率及剖宫产率等。结果中药组使用中西医结合治疗ICP,收到了满意的效果。与单纯西药治疗的对照组比较,皮肤瘙痒减轻快,ALT、AST、血总胆汁酸3项生化指标下降快,2组之间4项观察指标的差异均有统计学意义。2组患者妊娠预后各项指标的差异均有统计学意义。结论中西医结合治疗ICP,可以显著改善母儿预后,剖宫产率明显下降,亦可大大减少围生儿病死率。

Objective To compare the intrahepatic cholestasis syndrome during pregnancy （ICP） the curative effect of two groups of treatment. Methods In our hospital from January 2010 to May 2014 in the hospital, 125 cases of ICP patients grouped prospective studies, statistical skin pruritus score, cereal third transaminase, aspertate aminotran-sferase, the improvement of blood total bile acid and the perinatal death rate and cesarean section rate , etc. Results Traditional Chinese medicine group with combining traditional Chinese and western medicine treatment of ICP , received satisfactory results. Compared with pure western medicine treatment of the control group , relieved skin itch quickly, cereal third transaminase, aspertate aminotransferase, blood total bile acid three biochemical index falling fast, four measures of observing the difference between two groups had statistical significance. From the point of change of the two groups of patients with pregnancy outcomes, Chinese medicine group and control group were statistically significant differences between the indicators. Conclusion Combining traditional Chinese and western medicine treatment of ICP, can significantly improve the prognosis, and cesarean section rate declined obviously, can greatly reduce the rate of perinatal disease.