奥曲肽联合经皮穿刺置管引流治疗胰腺假性囊肿疗效分析

Analysis on the effect of treatment of octreotide combined with percutaneous catheter drainage on Pancreatic Pseudocyst

目的：观察奥曲肽联合经皮穿刺置管引流治疗胰腺假性囊肿（ PPC）的疗效。方法选择PPC患者89例，按随机数字表法分为奥曲肽联合经皮穿刺置管引流组（观察组，n＝43）和奥曲肽组（对照组，n＝46），对照组给予奥曲肽0．1 mg，每8小时1次皮下注射。观察组给予奥曲肽0．1 mg，每8小时1次皮下注射；B超或CT引导下经皮穿刺引流，持续引流观察4周，有多个囊肿，则放置多根引流管，引流不畅时需冲洗引流管并调整引流管位置。4周后即复查胰腺CT并进行疗效分析。结果观察组治愈率、总有效率、平均住院时间分别为65％、100％、（16．8±12．1） d，对照组分别为39％、85％、（26．8±19．4） d，两组差异均有统计学意义（χ^2＝6．01、χ^2＝7．10、t＝2．89，P＜0．05或P＜0．01）。结论奥曲肽联合经皮穿刺置管引流治疗PPC疗效佳，创伤小，成功率高，并发症少，住院时间短，是治疗PPC的首选方法。

Objective To observe the effect of octreotide combined with percutaneous catheter drainage on pancreatic pseudocyst （ PPC ） .Methods 89 patients choosen with PPC were randomly divided into the octreotide combined with percutaneous catheter drainage group（observation group,n=43） and octreotide group （control group, n=46）.The control group were subcutaneous injected octreotide 0.1mg q 8 h.The observation group were subcutane-ous injected octreotide 0.1mg q 8 h with ultrasound or CT-guided percutaneous drainage for 4 weeks to place more drainage tubes when there were multiple cysts,drainage not free when washing drainage tube and drainage tube posi-tion adjustment.After 4 weeks rechecked the pancreas CT and curative effect was analyzed.Results The observation group cure rate and total effective rate were 65%,100%,the average hospitalization time was （16.8 ±12.1） d.The control group were 39%,85%,（26.8 ±19.4） d,the differences between the two groups were statistically significant（χ2 =6.01,χ2 =7.10,t=2.89,P〈0.05,P〈0.01）.Conclusion Octreotide combined percutaneous catheter drainage on PPC has good curative effect,small trauma,high success rate,less complications,shorter hospitalization time.It is the preferred method for the treatment of PPC.