牛痘疫苗致炎兔皮提取物治疗糖尿病周围神经病变的临床探讨

The clinical effects of cowpox vaccination in inflammatory skin extract in the treatment ofdiabetic peripheral neuropathy

目的：探讨牛痘疫苗致炎兔皮提取物对糖尿病周围神经病变（ DPN）患者血同型半胱氨酸（Hcy）和胰岛素样生长因子（IGF－1）的影响。方法100例DPN患者按随机数字表法分为观察组50例、对照组50例。观察组采用牛痘疫苗致炎兔皮提取物治疗，对照组采用甲钴胺治疗，均治疗15 d。测定治疗前后总症状评分（TSS）、正中神经、腓总神经的运动神经传导速度（MCV）和感觉神经传导速度（SCV）及治疗前后血Hcy和IGF－1。结果两组治疗后TSS均有明显降低（t＝9．772、13．624，均P＜0．01），并且观察组较对照组降低更明显（t＝3．925，P＜0．05）。治疗后两组正中神经、腓总神经MCV和SCV均有明显增加（t＝5．105、3．019、4．998、2．928、5．128、3．112、5．286、3．118，均P＜0．05），并且观察组治疗后较对照组增加更明显（t＝2．826、2．743、3．268、3．096，均P＜0．05）。两组治疗后血IGF－1均有明显升高，并且观察组治疗后较对照组升高更明显（t＝4．179，P＜0．05）。两组治疗后血Hcy均有明显降低，并且观察组治疗后较对照组降低更明显（t＝3．165，P＜0．05）。结论牛痘疫苗致炎兔皮提取物可以明显改善DPN患者血Hcy和IGF－1的表达。

Objective To study the effectiveness of vaccinia vaccination rabbit inflammatory skin extracts on blood homocysteine（Hcy） and insulin-like growth factor-1（IGF-1） in patients with diabetic peripheral neuropathy. Methods 100 patients with diabetic peripheral neuropathy were randomly divided into the two groups,the observa-tion group（n=50 cases） and the control group（n=50 cases）.The observation group was treated through vaccinia vaccination rabbit inflammatory skin extracts, while the control group was treated through mecobalamin.They were treated for 15 days.Median nerve,peroneal motor nerve conduction velocity （MCV） and sensory nerve conduction velocity （ SCV） were determined before and after treatment.Blood IGF-1 and Hcy were detected.Results TSS were significantly lowered after treatment （t=9.772,13.624,all P〈0.01）.Compared with the control group,the observa-tion group was significantly decreased （t=3.925,P〈0.05）.After treatment,the median nerve,peroneal nerve MCV and SCV were significantly increased （t=5.103,3.019,4.998,2.928,5.128,3.112,5.286,3.118,all P〈0.05）. Compared with the control group,theobservation group was observed to increase more significantly（t=2.826,2.743, 3.268,3.096,all P〈0.05）.After treatment,serum IGF-1 were significantly elevated,and compared with the control group after treatment,post-treatment observation group increased more significantly（t=4.179,P〈0.05）.After treat-ment plasma Hcy were significantly lower than that of the control group after treatment,the observation group after treatment significantly decreased（t=3.165,P〈0.05）.Conclusion Vaccinia vaccination rabbit inflammatory skin extracts can improve blood Hcy and IGF-1 in patients with diabetic peripheral neuropathy.