槲皮素嵌段共聚物胶束大鼠体内药动学研究

Pharmacokinetics of Quercetin Block Copolymer Micelle in Rats

目的研究槲皮素嵌段共聚物胶束在大鼠体内的药动学。方法采用薄膜分散法制备槲皮素嵌段共聚物胶束。以槲皮素溶液剂为对照,考察胶束大鼠静脉注射后的药动学。采用3p97程序计算药动学参数。结果胶束在大鼠体内过程符合二室模型,其中溶液剂的t1/2β为9.15±4.91 min,AUC为36.55μg·min·m L-1;胶束t1/2β为40.28±2.53 min;AUC为84.97μg·min·m L-1。结论胶束能明显延长槲皮素在体内滞留时间,提高药物的生物利用度。

Objective To study the pharmacokinetics of Quercetin block copolymer micelle in rat, Methods Quercetin block copolymer micelle was prepared by thin film dispersion （TFD）. Quercetin Micelle injection Pharmacokinetic parameters had been modeled witb 3p97 program comparing with quercetin solution. Results The concentration-time curve of micelle after iv were in accordance with a two-compartment model, The main Pharmacokinetic parameters were as follows： Quercetin Solution：t1/2β 9.15±4.91 rain, AUC 36.55 μg·min·mL^-1; Quercetin micelle： t1/2β40.28±2.53 min, AUC84.97 μg·min·mL^-1. Conclution Micelle could extend the retention time ofquercetin and improve drug bioavailability in rats.