血浆纤维蛋白原水平在卵巢肿瘤临床诊断中的作用

Application of fibrinogen detection in the clinical diagnosis of ovarian tumors

目的探讨血浆纤维蛋白原(FIB)水平在卵巢肿瘤临床诊断中的价值。方法选择2012年3月至2013年9月间诊治的120例原发上皮性卵巢癌患者为观察组,100例卵巢良性肿瘤患者为对照组。分析两组患者的血浆FIB水平,以及不同分期的原发上皮性卵巢癌患者血浆FIB水平、和不同临床病理因素的原发性卵巢上皮癌患者血浆FIB水平。结果观察组患者血浆FIB水平增高的发生率为40.0%,对照组为7.0%,差异有统计学意义(2=7.81,P=0.028)。不同分期的原发上皮性卵巢癌患者血浆FIB水平之间差异有统计学意义(P<0.05)。随着原发上皮性卵巢癌分期的升高,血浆FIB水平增高的发生率也增加(2=6.98,P=0.041)。早期(Ⅰ、Ⅱ期)和晚期(Ⅲ、Ⅳ期)原发上皮性卵巢癌患者的血浆FIB水平之间差异有统计学意义(t=7.21,P=0.036)。不同组织学分级和不同腹水量患者的血浆FIB水平增高的差异无统计学意义(P>0.05),但在术后残留病灶>2 cm的患者中,血浆FIB增高的发生率高于≤2 cm者,差异有统计学意义(2=7.60,P=0.031)。结论血浆FIB水平对于原发上皮性卵巢癌患者的病情诊断和评估有一定的价值。

Objective To explore application value of plasma fibrinogen （FIB） detection in the clinical diagnosis of ovarian tumors. Methods A total of 120 patients with primary epithelial ovarian cancer were choosen from Armed Police Corps Hospital of He＇ nan as the observation group, 100 patients with benign ovarian tumors as the control group. Comparative analysis of plasma FIB level of two groups of patients, plasma FIB level of primary epithelial ovarian cancer in different stages, plasma FIB level of primary epithelial ovarian cancer early （Ⅰ, Ⅱ period） and late （Ⅲ, Ⅳ period） stage and plasma FIB level of various clinicopathological factors of primary epithelial ovarian cancer. Results In the observation group, patients had elevated plasma FIB level of 40. 0%, and 7. 0% in the control group, the difference was statistically significant （x^2 =7. 81, P=0.028）. Differences in plasma FIB level of primary epithelial ovarian cancer between the various stages was statistically significant （P 〈0. 05）. With the increase of primary epithelial ovarian cancer staging, patients with increased levels of plasma FIB ratio also increased （x^2 = 6. 98, P = 0. 041 ） . The differences of plasma FIB level between primary epithelial ovarian cancer early （ Ⅰ , Ⅱ period） and late （ Ⅲ, Ⅳ period） stage was statistically significant （t =7. 21, P =0. 036）. The differences of increased plasma FIB level in different histological grade and different amount of ascites were no significant （P 〉 0.05 ） , but in the swollen postoperative residual lesions 〉 2 cm patient ratio is higher than 42 cm, and the difference was statistically significant （ x^2 = 7.60, P = 0. 031 ）. Conclusion Monitoring plasma FIB level have a clinical value for diagnosis and assessment of patients with primary epithelial ovarian cancer.