子宫内膜息肉的分子生物学研究

Advances in Molecular Biology Research on Endometrial Polyps

子宫内膜息肉(endometrial polyps,EP)为妇女最常见的子宫内膜病变之一,常不合并临床症状,但部分患者可表现为异常子宫出血、不孕、甚至恶性变,严重降低了妇女的生活质量。因此,明确其病因及发病机制是防治该病的基础。目前多数研究认为其发生可能与雌、孕激素受体的异常分布以及局部内膜增生与凋亡的失衡等因素有关,但研究结果不尽相同。此外,有报道称,酶的异常表达、细胞因子及遗传因素等亦可能参与其发生发展。所有相关因素需在严格的质量管理及数据控制下进行更深一步的探讨,综述对其发病机制的分子生物学研究现状。

Endometrial polyps （EP） is one of the most common endometrial diseases. Patients having it may be totally asymptomatic. While some combined abnormal uterine bleeding, infertility,and even malignant conditions,severely reducing the quality of women＆#39;s life. Therefore, pinpointing the etiology and pathogenesis is the basis for prevention and treatment of diease. At present most scholars believe that the possible causes include abnormal distribution of estrogen receptor and progesterone receptor,partly endometrial proliferation and apoptosis disequilibrium,but the findings are not the same. In addition,abnormal expression of enzyme,cytokine and genetic factors,and so on, may also be involved in the development of its occurrence. All related factors need to be explored seriously under strict quality management and data control. This article reviews the advances in molecular biology research on endometrial polyps.