1621例不孕不育患者生殖道分泌物支原体感染及药敏分析

Analysis on mycoplasma infection from genital tract secretion and drug sensitivity in 1621 infertility patients

目的了解本地区不孕不育患者泌尿生殖道支原体感染状况并进行药敏分析,指导临床合理用药。方法对2013年10月-2014年7月到我院不孕症门诊就诊的不育不孕患者进行支原体培养、鉴定及药敏试验,并进行统计分析。结果在916例阳性患者中,女性患者Uu检出率62.16%,男性患者检出率48.59%。19岁~34岁组支原体感染率为57.53%,35岁~50组感染率为48.31%。单纯Uu感染741例占80.9%;单纯Mh感染11例占1.20%;Uu＋Mh混合感染164例占17.9%;可见泌尿生殖道感染以Uu感染为主。药敏结果显示Uu和Uu＋Mh两种感染均对交沙霉素、美满霉素、强力霉素的敏感性强。结论本地区不孕不育患者泌尿生殖系支原体感染中,男性与女性感染率有显著差异;19岁~34岁组支原体感染率高于35岁~50组;Uu感染率最高,其次为Uu＋Mh混合感染;交沙霉素、美满霉素、强力霉素可以作为本地区治疗Uu和Uu＋Mh混合感染的首选。并且在临床治疗时,医生应根据药敏实验结果,合理选择有效的抗生素,以达到有效治疗的目的。

Objective To investigate the genitourinary mycoplasma infection in infertility patients,and analyze the drug sensitivity in order to instruct the clinical rational administration.Methods By statistical analysis,the patients who hospitalized in our fertility clinics from Oct.2013 to July 2014 were tested for mycoplasma culture and drug sensitivity. Results In 916 cases,mycoplasma infection rates in male and female were 62.16% and 48.59%respectively. In age of 19~34 years old group, mycoplasma infection rates was 57.53%, in 35~50 years old group,infection rates was 48.31%. There were 741 cases with simple Uu infection（accounted for 80.9%）,11 cases with simple Mh infection（accounted for 1.20%）,and 164 cases with Uu＋Mh mixed infection（accounted for 17.9%）.It showed that Uu infection was predominant form in genitourinary infection.Drug sensitivity results showed that Uu and Uu＋ Mh mixed infection all had high sensitivity to josamycin, minocycline and doxycycline. Conclusion The genitourinary mycoplasma infection rates in male and female of infertility patients are significant different.In the age of 19 ~34 years old group, mycoplasma infection rate is higher than that in 35 ~50 group. Uu has the highest infection rate followed by Uu＋ Mh mixed infection. Josamycin, minocycline and doxycycline were the first choices for the treatment of Uu and Uu＋ Mh infection.The treatment should be based on the drug sensitivity test results.