5-芳胺基异噁唑的合成及表征

Synthesis and Characterization of 5-Arylamino Isoxazole Derivatives

以ɑ-乙酰基环丙基乙酰芳胺、盐酸羟胺为原料,通过亲核取代反应合成了1-环丙基-N-苯基酰胺肟,在脱水剂PPh3/CBr4作用下,使用"一锅法"合成了具有专一结构的2-甲基-1-溴乙基-5-芳胺基异噁唑,并对该产物进行了1 H NMR和13 C NMR表征.

1—cyclopropyl—N—phenyl amide oxime was synthesized from a—acetyl cyclopropyl acetanilide and hydroxylamine hydrochloride by nucleophilic substitution.2—methyl—1—ethyl—5—arylamino isoxazole was obtained from 1—cyclopropyl—N—phenyl amide oxime by one pot method under the dehydrating agent.The structures of the products were characterized by 1 H NMR and 13 C NMR.