D-二聚体与急性冠脉综合征冠脉病变的相关性

Correlation of D-dimer with coronary artery lesions in acute coronary syndrome

目的观察急性冠脉综合征(ACS)患者血中D-二聚体(D-dimer)水平,探讨其与急性冠脉综合征(ACS)冠状动脉病变程度的关系以及临床应用价值。方法 60例ACS患者[包括急性心梗(AMI)30例和不稳定型心绞痛(UAP)30例]作为研究组,另选30例健康体检者作为对照组;所有人均取外周静脉血检测D-dimer水平。冠状动脉病变进行Gensini评分,分析ACS患者D-dimer水平与Gensini评分的关系。结果 ACS(包括AMI和UAP)组与对照组比较,D-dimer水平明显增高,差异有统计学意义(P<0.01)。AMI组与UAP组Gensini评分的差异具有统计学意义(P<0.01)。相关性检验显示,ACS患者血D-dimer水平与Gensini评分成正相关(r=0.586,P<0.01)。结论 ACS患者血D-二聚体水平与冠状动脉病变程度密切相关。

Objective To explore the correlation of D-dimer with coronary artery lesions in patients with acute coronary syndrome （ACS）.Methods Sixty patients with ACS were enrolled in this study,including 30 patients with acute myocardial infarction（AMI） and 30 patients with unstable angina pectoris（UAP）.Thirty healthy subjects were chosen as controls.The peripheral venous blood were taken in all patients to detect the level of D-dimer.The lesions of coronary arteries were assessed by Gensini score.The relation of serum D-dimer with Gensini score was analyzed in ACS patients.Results The level of D-dimer was higher in ACS group（inclding AMI and UAP） than that in control group（P ＜ 0.01）.Gensini score was significantly higher in AMI group than in UAP group （P ＜ 0.01）.The level of D-dimer was positively related with Gensini score in ACS patients （r =0.586,P ＜ 0.01）.Conclusion Level of D-dimer in patients with ACS may be closely related to the atherosclerostic lesions of coronary arteries.