-硫辛酸血栓通联合治疗糖尿病周围神经病变疗效分析

The rapeutic effect of Xueshuantong and Alpha lipoic acid on diabetic peripheral neuropathy

目的探讨a-硫辛酸治疗糖尿病周围神经病变的临床效果。方法选择糖尿病合并周围神经病变患者60例,分为治疗组(30例)和对照组(30例),对照组给予常规控制血糖及血栓通450 mg,每天1次,治疗组在对照组基础上加用硫辛酸600 mg,每天1次,治疗2周,并比较2组临床疗效。结果治疗组总有效率为93.3%,高于对照组的66.7%,差异具有统计学意义(P<0.05),且治疗组临床症状及体征改善明显。结论硫辛酸治疗糖尿病周围神经病变(DPN)效果显著,安全性高,值得临床推广应用。

Objective To evaluate the therapeutic effects of anti-oxidant alpha lipoic acid on diabetic periph- eral neuropathy. Methods A total of 60 patients of type 2 diabetes mellitus with varying degrees of neuropathy were randomly divided into two groups. The control group （n = 30） was treated with conventional glucose control and Xueshuantong 450 mg/d, while the treatment group （n =30） received extra alpha lipoic 600 mg/d. Both treatments lasted for 2 weeks. Results The total effective rate in improvement of clinical symptoms was 93.3% in the treatment group and 66. 7% in control group. There was significant difference between these two groups （P〈 0.05）. The clinical symptoms and physical signs in the treatment group were significantly improved. Gonclusion Alpha lipoic acid is safe and effective in treating DPN, which is worthy of popularizing.