孕期持续性有机污染物暴露对妊娠结局和婴幼儿生长发育的影响

Impact of exposure to persistent organic pollutants during pregnancy on pregnancy outcome and infant growth and development

环境改变和污染所引起下一代的变化是深刻的,其中胎儿则是最敏感的人群之一。持续性有机污染物(POPs)是环境中很重要的一类化学污染物,随着气候变化和经济快速发展使得其暴露水平和模式也发生改变^([1])。虽然许多POPs在多年前已被淘汰,但由于它们具有持久性、亲脂性、生物累积性、半挥发性和高毒性,在环境中仍有残留。目前国内外动物实验和人群流行病学调查研究显示,孕期暴露POPs可能会对妊娠结局及儿童生长发育产生不良影响。其中包括低出生体质量、早产、出生缺陷、儿童神经系统和生殖系统发育不良等,本文以人群流行病调查资料为基础对孕期暴露POPs对下一代产生的上述影响进行阐述。

Environmental changes and pollution have profound effects on the fetus. Persistent organic pollutants （POPs） are a very important category of chemical pollutants in the environment. With the rapid deterioration of the climate, the exposure levels and patterns of POPs have changed. Although many POPs were eliminated years ago, due to their persistence, lipophilicity, bioaccumulation, semi volatility and high toxicity, there are still residual POPs in the environment. Current animal experiments and epidemiological researches home and abroad have showed that prenatal exposure to POPs may have adverse effect on pregnancy outcome and infant growth and development, including low birth weight, premature birth, birth defects, dysplasia of nervous and reproductive systems. This paper reviewed the effects of POPs exposure on fetus based on population-based epidemiological survey data.