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血管抑素对碱烧伤大鼠角膜炎症的抑制作用及机制 被引量：3

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摘要 目的研究血管抑素(AS)对碱烧伤大鼠角膜炎症反应及炎症细胞浸润的抑制作用,并初步探讨其作用机制。方法 120只SD大鼠左眼氢氧化钠烧伤制备碱烧伤模型,随机分成A、B、C、D 4组,分别予生理盐水、0.1 mg/m L地塞米松、10μg/m L及20μg/m L AS点眼治疗4次/d。烧伤后1、3、7、14、21 d每组随机取6只大鼠裂隙灯下观察结膜充血、角膜水肿及浑浊情况后处死,取左眼角膜均分两半,一半行组织病理切片及炎症细胞计数,另一半行IL-1α的ELISA检测,比较各组大鼠角膜炎症反应、炎症细胞浸润及IL-1α表达情况。结果 B、C、D组在烧伤后各时间点角膜炎症反应及浑浊度均较A组轻(P<0.05);炎症细胞计数均少于A组,差异有统计学意义(P<0.05)。B、C、D组各时间点大鼠角膜的IL-1α表达水平低于A组(P<0.05)。结论 AS可以抑制碱烧伤大鼠角膜的炎症反应及炎症细胞浸润,其机制可能是抑制IL-1α的表达。
作者 曾静 罗殿中 党裔武
机构地区 广西医科大学第一附属医院眼科 广西医科大学第一附属医院病理科
出处 《广东医学》 CAS CSCD 北大核心 2014年第23期3639-3642,共4页 Guangdong Medical Journal
基金 广西自然科学基金资助项目(编号:桂科自0728131) 广西教育厅研究生科研创新基金(编号:2008105981001D24)
关键词 血管抑素 角膜 碱烧伤 炎症
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献10

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二级参考文献10

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共引文献4

同被引文献32

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引证文献3

二级引证文献10

广东医学
2014年 第23期

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