结肠癌转移相关基因1在宫颈鳞癌中的表达及其与预后的关系

Expression of metastasis- associated in colon cancer- 1 (MACC1) in cervical carcinoma and its association with prognosis

目的探讨结肠癌转移相关基因1(MACC1)在宫颈鳞癌组织中的表达,并分析其与预后的关系。方法采用免疫组织化学检测63例宫颈鳞癌组织和相对应的63例正常宫颈上皮组织中MACC1蛋白的表达,并分析其与临床病理学参数及预后的关系。结果 MACC1在宫颈鳞癌组织中阳性表达率(65.08%,41/63)显著高于正常宫颈上皮组织(23.81%,15/63),差异有统计学意义(P<0.05)。MACC1蛋白表达与患者的组织学分化、临床分期、浸润深度和淋巴结转移密切相关(P<0.05),但与患者年龄无关(P>0.05)。MACC1阳性表达的宫颈鳞癌患者存活时间明显短于MACC1阴性表达的宫颈鳞癌患者(P<0.05)。结论 MACC1与宫颈鳞癌的发生发展关系密切,其表达高低有望成为宫颈鳞癌恶性程度及预后的判定指标。

Objective To investigate the expression of metastasis - associated in colon cancer - 1 （ MACC1 ） in cervical carcinoma tissues and analyze its association with the prognosis. Methods Expression of MACC1 protein was detected by immuno - histochemistry in 63 samples of cervical carcinoma tissues and 63 samples of paired normal cervical epithelial tissues, and its associations with clinicopathological features and prognosis were also investigated. Results Positive expression ratio of MACC1 in cervical carcinoma tissues （65. 00% , 41/63） was significantly higher than that in normal cervical epithelial tissues （23.81% , 15/63, P 〈 0. 05 ）. Expression of MACC1 protein was tightly associated with histological differentiation, clinical staging, invasion depth and lymph node metastasis of the patients with cervical carcinoma （P 〈0. 05）, but not related to the age （P 〉 0. 05 ）. Furthermore, the survival time of the patients with MACC1 at high level was significantly lower than those with MACC1 at low level （P 〈 0. 05 ）. Conclusion MACC1 is closely associated with the occurrence and development of cervical carcinoma, and its expression level may be a predictor for malignant degree and prognosis of cervical carcinoma.