2156名女性患者人乳头瘤病毒检测结果分析

Genotyping results analysis of 2156 cases of female HPV

目的：了解丽水地区妇女宫颈人乳头瘤病毒（HPV）感染的阳性率与各年龄组关系及亚型分布情况,为该地区宫颈癌防治及流行病学研究提供依据。方法：采用DNA反向斑点杂交技术对2 156名妇女宫颈脱落细胞标本进行21种HPV基因型检测,统计分析HPV感染的阳性率和年龄组的关系及亚型分布特点。结果：2 156例标本中阳性944例,阳性率为43.8%。检出前8位亚型优势型别依次为16、58、52、66、53、68、51、33。HPV感染的高峰年龄是30～50岁,检出率最高的年龄组是〉60岁的人群,其次是50～60岁年龄组。各年龄组的HPV阳性检出率及优势亚型检出率有显著差异。结论：HPV基因分型检测对宫颈癌的防治有重要意义。

Objective To provide reference for the prevention and epidemiological study of cervical cancer by investi- gating the relationship between the positive rate of female HPV infection and each age group as well as the distribution of each subtype in Lishui region. Methods We detected 21 kinds of HPV genotype using dot blot hybridization reverse-- gene chip to detect 2156 cases of female cervical exfoliated cells and calculated the relation between the positive rate of female HPV infection and age. Results Nine hundred and forty--four of 2156 cases were positive,with a positive rate of 42.8%. Among the 944 positive samples, HPV 16,58,52,66,53,68,51 and 33 were the top eight dominant subtypes. The peak age of HPV infection ranged from 30 to 50 years old. The group with the highest detection rate is that above 60 years old, followed by that between 50 to 60 years old. The positive detection rates of HPV infection and dominant subtype detection rates had significant differences among age groups. Conclusions HPV genotyping detection is mean- ingful for prevention and control of cervical cancer.