丙氨酰-谷氨酰胺肠外营养在肠梗阻治疗中的临床观察被引量：1

Therapeutic effects of parenteral nutrition with alanyl-glutamine in treating intestinal obstruction

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摘要目的探讨丙氨酰-谷氨酰胺肠外营养在肠梗阻治疗中的临床效果。方法 41例肠梗阻患者分为一般治疗组(对照组)和应用丙氨酰-谷氨酰胺特殊治疗组(治疗组),两组患者均采用非手术治疗措施,治疗组在常规治疗基础上加用N(2)-L-丙氨酰-L-谷氨酰胺注射液肠外营养。观察两组患者治疗前后血浆白细胞、白蛋白、C-反应蛋白等变化。结果应用谷氨酰胺后,治疗组血浆白蛋白较对照组有显著升高,差异有统计学意义(P<0.05),治疗组超敏C-反应蛋白、白细胞均较对照组有显著降低,差异有统计学意义(P<0.05)。结论丙氨酰-谷氨酰胺在肠梗阻患者中使用安全,有助于改善患者营养状况、缓解症状,减少住院天数。 Objective To investigate the therapeutic effects of parenteral nutrition with alanyl -glutamine in treating intestinal obstruction .Methods Forty-one cases of intestinal obstruction were divided into conventional group （ Control group ） and alanyl glutamine group （ Alanyl-Glutamine group ） .Both groups were treated without surgical operation .Alanyl-Glutamine group were provided N （2） -L-alanyl glutamine injection for parenteral nutrition in addition to Control treatment .The changes of plasma cells , albumin and C-reactive protein in two groups were observed before and after treatment .Results Application of glutamine group after treatment , the plasma albumin were significantly increased , the difference was statistically significant （ P 〈0.05）, the Alanyl-Glutamine group of high sensitivity C-reactive protein and white blood cells were lower than those in the control group were significantly decreased , the difference was statistically significant （P〈0.05）.Conclusions Alanyl glutamine is safe in patients with intestinal obstruction , help to improve the nutritional status of patients , relieve symptoms , and reduce the hospitalization days .

作者张秀敏姜燕李雪

机构地区江苏省连云港市第二人民医院消化科江苏省连云港市药品检验所

出处《齐齐哈尔医学院学报》 2014年第24期3601-3603,共3页 Journal of Qiqihar Medical University

关键词丙氨酰谷氨酰胺肠外营养肠梗阻 Alanyl glutamine Parenteral nutrition Intestinal obstruction

分类号 R459.3 [医药卫生—治疗学]

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1沈通一,秦环龙.谷氨酰胺对肠屏障功能保护作用的研究进展[J].肠外与肠内营养,2003,10(3):177-180. 被引量：33
2Salloum RM, Souba WW, et al. Dietary modulation of small intestimal glutamnine transport in intestinal brush border membrane vesieles of rats[J]. Surg Res,1990,48(6) :635-638.
3Coffier M, Claeyssens S, Lecleire S. Combined enteral infusion of glutamine, carbohydrate and antioxidants modulates gut protein metabolism in humans[ J ]. Am J Clin Nutr, 2008,88 (5) :1284- 1290.
4Mularski RA, Heine CE, Osborne ML, et al. Quality of dying in the ICU :ratings by family members[J]. Chest,2005,128( 1 ) :280- 287.

二级参考文献24

1Madsen KL,Doyle JS,Jewell LD et al. Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice[ J ]. Gastroenterology, 1999,116(5) :1107-1114.
2Detich EA. Bacterial translocation of the gut flora[ J ]. J Trauma,1990,30(12) :184-189.
3Buchman AL. Glutamine:commercially essential or conditionally essential? A critical appraisail of the human data[ J ]. Am J Clin Nutr,2001,74( 1 ) :25-32.
4Jiang ZM ,Cao JD,Zhu XG et al. The impact of alany-glutamine on clinical safaty, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients: a randomized, doubleblind, controlled study of 120 patients[ J ]. JPEN, 1999,23 ( 5 ) :S62.
5Papaconstantinou HT, Hwang KO, Rajaraman Set al. Glutamine deprivation induces apoptosis in intestinal epithelial cell [ J ]. Surgery, 1998,124(2) :152-160.
6Bochman AL. The use of glutamine in parenteral nutrition [ J ].Gastroenterology, 1995,108 (6) : 1961-1963.
7Wischmeyer PE, Lynch J, Liedel J a al. Glutamine administration reduces Gram-negative baeteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control [ J ]. Crit Care Med ,2001,29 ( 11 ) :2075-2080.
8Daniele B, Pert'one F, Gallo C et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind,placebo controlled, randomized trail [ J ]. Gut, 2001,48 ( 1 ) : 28-33.
9Calder PC. Glutamine and the immune system [ J ]. Amino Acids,1999,17(3) :227-241.
10Furukawa S,Saito H, Fukatsu K et al. Glutamine-enhanced bacterial killing by neutrophis from postoperative patients[ J ]. Nut,1997,13(10) :863-869.