抗CCP抗体与类风湿关节炎及SLE关节炎的相关性研究

Research on correlation of anti-CCP antibody with rheumatoid arthritis and SLE-derived arthritis

目的研究抗环瓜氨酸肽(CCP)抗体在风湿性疾病中的临床意义,探讨抗CCP抗体在类风湿关节炎(RA)和系统性红斑狼疮(SLE)及其他风湿性疾病诊断中的应用价值。方法采用酶联免疫吸附实验(ELISA)方法检测150例RA患者、120例SLE患者及100例健康人血清中的抗CCP抗体,并对3组检测结果进行相关性分析。结果抗CCP抗体在RA组中的敏感性为77.3%,特异性为95.9%,抗CCP抗体在SLE患者组中的敏感性为6.7%,特异性为44.8%。RA组的抗CCP抗体的敏感性及特异性均明显高于SLE组及健康对照组,差异有统计学意义(P<0.05);SLE患者中关节炎组的抗CCP抗体阳性率为9.5%,较非关节炎组(3.5%)高,差异有统计学意义(P<0.05)。结论抗CCP抗体可作为RA诊断的良好指标,抗CCP抗体与SLE患者关节炎的发生及骨侵蚀密切相关。

Objective To explore the clinical significance of anti- CCP antibody in curing rheumatic diseases,and the application value in diagnoses of rheumatoid arthrit（ RA）,SLE and other rheumatoid diseases. Methods Detected serum anti- CCP antibody（ anti- CCP） in 150 cases RA,120 cases SLE and 100 cases healthy control using enzyme- linked immuno sorbent assay（ ELISA）,and conducted correlation analysis in RA,SLE and healthy control. Results In RA group,sensitivity of anti-CCP was 77. 3%,specificity was 95. 9%,and in SLE group,sensitivity rate of anti- CCP was 6. 7%,specification rate was44. 8%. The anti- CCP positive rate and specificity of RA group were all significantly higher than that in SLE group and healthy control group,the difference was statistically significant（ P 〈 0. 05）. In SLE group,the incidence of arthritis was higher than non- arthritis,positive rate（ 9. 5%） of anti- CCP was higher than non- arthritis group（ 3. 5%）,the difference was statistically significant（ P 〈 0. 05）. Conclusion Anti- CCP can be used as one of the good index for RA diagnosis,and is intimately related with developing of arthritis and bone erosion in SLE.