肺腺癌患者EGFR突变与TTF-1的关系及意义研究

Research of relation and significance between EGFR mutations and TTF- 1 in lung adenocarcinoma

目的分析肺腺癌患者EGFR突变与TTF-1及患者临床相关因素的相关性。方法对247例肺腺癌组织标本进行TTF-1及EGFR检测,分析两者间的相关性及临床意义。结果肺腺癌EGFR突变97例(39.27%),其中19外显子缺失突变27例(10.93%),21外显子点突变70例(28.34%);EGFR突变者均为TTF-1染色阳性,而TTF-1阴性或部分阳性者无1例有EGFR突变,EGFR突变与TTF-1表达具有明显相关性(P=0.0057);TTF-1阳性、女性、不吸烟、血清CEA异常(≥5 ng/ml),肿瘤远处转移患者EGFR突变率较高。结论肺腺癌患者EGFR突变与TTF-1呈明显正相关性,TTF-1表达情况在一定程度上可预测肺腺癌EGFR突变状况,为临床治疗决策提供有意义的线索。

Objective To analyze the relationship between EGFR mutations and TTF -1 in patients with lung adenocarcinoma.Methods 247 cases with lung adenocarcinoma were collected to detect TTF-1 and EGFR mu-tations,then to analysis the relationship between EGFR mutations and TTF-1 .Results There were 97 cases of EG-FR mutations （39.27%）,including 27 cases of 1 9-exons deletion （1 0.93%）and 70 cases of 21-exons point muta-tions （L858R）.The cases of EGFR mutations all had positive TTF-1 .EGFR mutation had clear correlation with the expression of TTF-1 （P=0.0057）.The high risk factors of mutation were positive expression of TTF-1 ,women,no smoking and abnormal serum CEA≥5 ng/ml.Conclusion EGFR mutation is related with the positive expression of TTF-1 in patients with lung adenocarcinoma.