孕期妇女全氟化合物暴露与婴儿期身心发育的相关性研究

Study on the correlation between maternal perfluorinated compounds exposure during pregnancy and physical and mental development of their infants

目的：了解孕期妇女日常生活中全氟化合物（PFCs）的接触情况及可能的暴露途径,并分析孕期妇女在受到PFCs的影响后与0-1岁婴儿身心发育的相关性,为孕期妇女保健和婴儿健康发展提供参考依据。方法：选取在某地医院体检的0-1岁婴儿,采用自编调查问卷和丹佛发育筛查量表（DDST）收集母亲孕期PFCs的接触信息及婴儿生理和心理发育情况,应用χ^2检验和多因素Logistic回归方法进行统计分析。结果：每天外出活动选择步行或电动车、母亲存在与PFCs相关的职业接触、每天饮用包装饮用水与生理发育相关,差异有统计学意义（P〈0.05）,且经多因素Logistic回归分析后得出这3个因素是影响婴儿生理发育的可能危险因素;每天饮用自来水可能是影响婴儿心理发育的因素。结论：孕期妇女应尽可能地避免PFCs接触,多了解孕期保健知识。同时相关部门应重视PFCs的危险性,做好卫生监督工作。

Objective： To understand the contact situation and possible pathways exposure to perfluorinated compounds during pregnancy in daily life, analyze the correlation with physical and mental development of their infants under one year, provide a reference basis for maternal health care during pregnancy and healthy development of infants. Methods： The infants under one year receiving physical examination in a local hospital were selected, a self - designed questionnaire and DDST were used to collect contact situation of perfluorinated comp6unds of their mothers and physical and mental development of these infants ; χ^2 test and multivariate Logistic regression analysis were used for Statistical analysis of data. Results： Daily excursions on foot or bicycle, maternal occupational exposure to perfluorinated compounds and drinking bottled water daily were correlated with physical development of the infants （ P 〈 0. 05 ）, multivariate Logistic regression analysis ~howed that the three factors were possible risk factors of physical development of the infants; drinking bottled water daily might be an influencing factor of mental development of the infants. Conclusion： The pregnant women should avoid perfluorinated compounds exposure as far as possible and learn more about antenatal care knowledge. In the meantime, the relevant departments should pay attention to the risk of perfluorinated compounds and health supervision.