摘要
目的：综合分析评价子宫内膜癌的高危因素,为制定预防措施提供依据。方法：计算机检索2000年1月-2014年1月Pubmed、Medline、CNKI、万方数据库、维普等数据库公开发表的关于子宫内膜癌危险因素的文献,按照Newcastle-Ottawa Scale的评价标准对入选文献进行质量评价,采用Revman 5.2软件进行Meta分析。结果：最终纳入12篇文献,经Meta分析计算合并OR值及其95%CI有显著性意义的因素为：肥胖2.39（1.48-3.84）、高血压4.28（2.42-7.75）、糖尿病2.52（2.15-2.95）、吸烟0.87（0.78-0.99）、恶性肿瘤家族史1.47（1.26-1.72）、未孕2.40（1.78-3.24）、激素替代治疗1.12（0.79-1.57）,P=0.53。结论：BMI≥25 kg/m2、高血压、糖尿病、吸烟、恶性肿瘤家族史、未孕是子宫内膜癌发生的高危因素,激素替代治疗不是子宫内膜癌发生的高危因素。
Objective： To analyze and evaluate the risk factors of endometrial cancer comprehensively, provide a basis for making preventive measures. Methods： The literature about the risk factors of endometrial cancer were searched in Pubmed, Medline, CNKI, Wan- fang and VIP from January 2000 to January 2014 by a computer, quality evaluation of these literature was performed according to evaluation criteria of Newcastle -Ottawa Scale, a meta analysis was conducted on RevMan 5.2 software. Results： A total of 12 articles were included in this study finally, the significant factors after calculating OR value and 95 % confidential interval （CI） included obesity （2. 39, 1.48 - 3.84）, hypertension （4. 28, 2.42 - 7. 75）, diabetes （2. 52, 2. 15 - 2. 95 ）, smoking （0.87, 0. 78 - 0.99）, family history of malignant tumor （ 1.47, 1.26 - 1.72）, unpregnaney （ 2.40, 1.78 - 3.24） and hormone replacement therapy （HRT） （ 1.12, 0.79 - 1.57 ） （ P = 0. 53 ） . Conclusion ： BMI ≥25 kg/m^2 , hypertension, diabetes, smok- ing, family history of malignant tumor and unpregnancy are risk factors of endometrial cancer, while HRT is not.
出处
《中国妇幼保健》
CAS
2015年第1期38-41,共4页
Maternal and Child Health Care of China
