狼疮性肾炎17例临床病理特点分析

目的：探讨狼疮性肾炎的临床病理学特点,提高对该病的认识。方法 ：搜集新疆医科大学第一附属医院病理科2010~2013年明确诊断为狼疮性肾炎的病例17例,回顾性分析该组病例的临床病理学资料,并对该组病例按照2003年国际肾病学会和肾脏病理学会工作组制定的狼疮性肾炎的病理学分型（ISN/RPS,2003）重新阅片分型。结果：狼疮性肾炎临床表现多样,多表现为急性肾炎综合征或肾病综合征,蛋白尿、血尿、肾衰竭都可能出现;病理分型以Ⅳ型（弥漫性）最为常见,且该型活动性和非活动性病变指数偏高。结论：狼疮性肾炎临床表现及病理学形态复杂多样,肾脏穿刺活检能够较好的判断患者病变类型,对于指导临床治疗及患者预后判断有一定指导作用。

Objective：To investigation the clinicopathological features of lupus nephritis and improve cognize about this disease. Methods： Collected seventeen cases which clearly diagnose as lupus nephritis in the pathology department of the first affiliated hospital of xinjiang medical university between 2010 and 2013, retrospectively analyzed the elinieopathological features and rechecked the sections according to the ISN/RPS pathological types of lupus nephritis. Results：Cinieal manifestations of lupus nephritis were in varied forms, the most common were acute nephritic syndrome and nephritic syndrome, albuminuria, hematuria, kidney failure all could appeared; pathological types were most common by type 1V which activity index and non activity index were high. Conelnsion：Cinical manifestations and histological patterns of lupus nephritis are complex, renal biopsy can judge pathological type preferably, which can guide treatment and estimate prognosis.