冠心病患者同型半胱氨酸、超敏C反应蛋白和心肌肌钙蛋白T检测的临床意义

Significance of detection of Hcy,hs-CRP and cTnT in patients with coronary heart diseases

目的研究冠心病患者血浆中同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)和心肌肌钙蛋白T(cTnT)变化的意义。方法收集2012年8月至2013年11月延安大学附属医院冠心病患者血清240例为冠心病组,以250例健康体检合格者作为对照组,分别采用循环酶法、免疫散射法、电化学发光法测定血清中Hcy、hs-CRP和cTnT的水平,采用统计学软件SPSS13.0进行数据分析。结果冠心病组患者血清Hcy、hs-CRP、cTnT水平分别为(24.89±17.78)μmol/L,(17.43±35.89)mg/L、(0.76±2.36)ng/mL。明显高于对照组(P<0.05)。且冠心病患者Hcy阳性率最高(81.25%),其次为hs-CRP(64.58%)与cTnT(58.75%)。结论 Hcy、hs-CRP与cTnT在冠心病的发生、发展中起重要作用,降低冠心病患者的Hcy水平可能是防治冠心病的重要途径。

Objective To study the significance of plasma homocysteine（Hcy） ,high sensitivity C-reactive protein（hs-CRP） and cardiac treponin T（cTnT） changes in the patients with coronary heart diseases（CHD）. Methods From August 2012 to November 2013,240 patients with CHD in our hospital were collected as the CHD group and 250 individuals of healthy physical examination served as the control group. Serum Hcy, hs-CRP and cTnT were detected by using the enzymatic cycle assay,immune scatter turbidimetry and electrochemiluminescence assay respectively. The data were statistically analyzed by the SPSS software. Results The serum levels of Hey, hs-CRP and cTnT in the CHD group were （24.89±17.78）μmol/L, （17.43±35.89）mg/L and （0.76± 2.36） ng/mL respectively, which were significantly higher than those in the control group（P〈0. 001）. Moreover, the positive rate of Hcy in the CHD group was the highest （81.25%） ,followed by hs-CRP（64.58%） and cTnT （58.75%）. Conehlsion Hcy,hs-CRP and cTnT played important roles in the development and progression of CHD,so reducing Hey level may be an important pathway for preventing and treating CHD.