CEA、CA125、LDH联合检测对良恶性胸、腹腔积液鉴别的临床应用

Clinical application of combined detection of CEA,CA125 and LDH in benign and malignant hydrothorax and ascites identification

目的探讨测定癌胚抗原(CEA)、糖类抗原125(CA125)和乳酸脱氢酶(LDH)在胸、腹腔积液良恶性鉴别诊断中的临床应用价值。方法应用Beckmancoulter ACCESS2全自动微粒子化学发光免疫分析仪测定胸、腹腔积液中CEA、CA125的水平,应用罗氏C501全自动生化分析仪测定胸、腹腔积液中LDH的水平,评价3项指标对胸、腹腔积液良恶性判断的临床应用价值。结果 CEA、CA125、LDH在良恶性胸、腹腔积液中的表达水平差异有统计学意义(P<0.05);CEA、CA125、LDH在恶性胸、腹腔积液中的阳性率分别为84.21%,92.98%,75.44%。结论联合检测CEA、CA125、LDH对良恶性胸、腹腔积液鉴别诊断有重要价值。

Objective To investigate the clinical application value of the determination of carcinoembryonic antigen （CEA） ,carbohydrate antigen 125 （CA125） and lactate dehydrogenase （LDH） in the differential diagnosis of malignant hydrothorax and asci- tes. Methods The Beckmancoulter ACCESS2 automatic micro particle chemiluminescence immunoassay analyzer was adopted to determine the CEA and CA125 levels in hydrothorax and ascites,and the Roche C501 automatic biochemical analyzer was used to determine the LDH level in hydrothorax and ascites. The clinical application value of these three indicators in the evaluation of benign and malignant hydrothorax and ascites was evaluated. Results The differences in the expression levels of CEA,CA125 and LDH between benign and malignant hydrothorax and ascites had statistical significance （P〈0. 01）;the positive rate of CEA, CA125 and LDH in malignant hydrothorax and ascites were 84.21%,92.98% ,75.44%. Conclusion The combined detection of CEA,CA125 and LDH has an important value in differential diagnosis of benign and malignant hydrothorax and ascites.