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匹多莫德治疗婴幼儿喘息的临床效果及其对免疫功能的影响 被引量:2

Clinical effect of pidotimod in the treatment of infant wheezing and its influence on immune function
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摘要 目的观察匹多莫德治疗婴幼儿喘息的临床疗效及对婴幼儿免疫功能的影响。方法 98例婴幼儿喘息患儿作为观察对象,随机分为两组,其中48例进行常规治疗,作为对照组,50例常规治疗同时联合使用匹多莫德,作为观察组。对两组的治疗效果及免疫学指标进行对比分析。结果观察组在治疗后显效33例,有效15例,无效2例,总有效率为96.00%,对照组显效17例,有效18例,无效13例,总有效率为72.92%,观察组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。观察组治疗后的CD3+CD4+,CD3+CD4+/CD3+CD8+指数明显高于对照组,观察组治疗后的Ig E指数明显低于对照组,差异均具有统计学意义(P<0.05)。结论匹多莫德在治疗婴幼儿喘息时有显著疗效,并能更好的保护婴幼儿的机体免疫系统,丰富了临床治疗的手段。 Objective To observe the clinical effect of pidotimod in the treatment of infant wheezing and its influence on infant’s immune function.Methods A total of 98 wheezing infants were taken as the observation subjects, and they were randomly divided into two groups. 48 cases among them received conventional treatment as control group, and the other 50 cases were given pidotimod combined with conventional treatment as observation group. Clinical effects and immunological indicators were compared and analyzed in the two groups.Results There were 33 cases with excellent effect, 15 effective cases, and 2 ineffective cases in the observation group, with the total effective rate as 96.00%. The control group contained 17 cases with excellent effect, 18 effective cases, and 13 ineffective cases, with the total effective rate as 72.92%. The total effective rate was obviously higher in the observation group than in the control group, and the difference had statistical significance (P〈0.05). After treatment, the observation group had remarkably higher CD3+CD4+, CD3+CD4+/CD3+CD8+ indicators and lower IgE index than the control group, and the differences all had statistical significance (P〈0.05).Conclusion Pidotimod provides precise effect in the treatment of infant wheezing with good protection of infant’s immune system. It brings new measure into clinical treatment.
出处 《中国现代药物应用》 2015年第4期8-10,共3页 Chinese Journal of Modern Drug Application
基金 支气管神经源性炎症在哮喘发生发展中的相互关系探讨(项目编号:20130319C)
关键词 匹多莫德 婴幼儿喘息 临床效果 免疫功能 Pidotimod Infant wheezing Clinical effect Immune function
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  • 1郭大东,高雪芹,朱波,韩金祥.人巨细胞病毒感染的检测方法[J].山东医药,2005,45(20):66-67. 被引量:2
  • 2张廷熹,鲍一笑,肖洁,岳孟源,董晓艳,王薇.匹多莫德口服液对儿童反复呼吸道感染的治疗作用[J].临床儿科杂志,2006,24(3):226-227. 被引量:11
  • 3贾黎红.匹多莫德口服液治疗儿童反复呼吸道感染疗效观察[J].实用医学杂志,2007,23(5):727-728. 被引量:33
  • 4Bisgaard H.Use of inhaled corticosteroids in pediatric asthma [J]. Pediatr Pulmonol, 1997,15(s) :27-33.
  • 5Kuehni CE~ Frey U.Age-related differences in perceived asthma control in childhood: guidelines and reality[J]. Eur Respir J, 2002,20 (4) : 880-889.
  • 6Jackson D J, Lemanske RF. The role of respiratory virus infections in childhood asthma inception[J], lmmunol Al- lergy Clin North Am, 2010,30(4) : 513-522.
  • 7Blom D, Ermers M, Bont L, et aL Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bron- chiolitic wheezing[J]. Cochrane Database Syst Rev, 2007,24(1) : CD004881.
  • 8Migliorati G, Nicoletti L, Riccardi C.Immumodulating ac- tivity of pidotimod[J]. Arzneim Forsch, 1994, 44 (12a) : 1421-1424.
  • 9陈玉娟.不同吸入疗法治疗喘息性疾病疗效观察[J].山东医药,2007,47(31):41-42. 被引量:3
  • 10Han J, Jia Y,Takeda K,et d.Montelukast during primary infection prevents airway hyperresponsiveness and infla- mmation after reinfection with respiratory syncytial virus[J]. Am J Respir Crit Care Med,2010,182(4) :455-463.

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