期刊文献+

影响儿童急性淋巴细胞白血病预后的因素分析 被引量:3

下载PDF
导出
摘要 目的对影响儿童急性淋巴细胞白血病预后的因素进行研究分析。方法对78例急性淋巴细胞白血病患儿临床资料进行研究分析,对其生存率、危险率变化进行分析,并对各因素相关性进行检验。结果 COX回归多因素分析结果显示:泼尼松诱导敏感度、外周血白细胞数、诱导35 d骨髓原始、治疗依从性、治疗期间是否出现复发等均为影响儿童预后的独立因素;患儿经积极治疗后,诱导缓解率为83.3%。结论初诊时对可能影响儿童急性淋巴细胞白血病预后的因素进行治疗及控制,治疗期间提高患儿依从性、实现个体化治疗对于改善预后,延长患儿生存率有着重要意义。
出处 《中国现代药物应用》 2015年第4期49-51,共3页 Chinese Journal of Modern Drug Application
  • 相关文献

参考文献4

二级参考文献54

  • 1顾龙君.儿童急性淋巴细胞白血病诊疗建议(第三次修订草案)[J].中华儿科杂志,2006,44(5):392-395. 被引量:476
  • 2Mann G, Attarbaschi A, Schrappe M, et al. Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed - lineage - leukemia (MLL) - rearranged acute lym- phoblastic leukemia : Results from the interfant - 99 study [ J ]. Blood, 2010,116 ( 15 ) :2644 - 2650.
  • 3M~ricke A, Reiter A, Zimmermann M, et al. Risk - adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and im- prove survival:Treatment results of 2169 unselected pediatric and ado- lescent patients enrolled in the trial ALL - BFM 95 [ J ]. Blood, 2008, 111(9) :4477 -4489.
  • 4Pui CH, Pei D, Sandlund JT, et al. Long - term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lym- phoblastic leukemia [ J ]. Leukemia,2010,24 ( 2 ) : 371 - 382.
  • 5Sallan SE, Schrappe M, Silverman LB, et al. Treating childhood leuke- mia without cranial irradiation[ J ]. N Engl J Med, 2009 (24) :1310 - 1312.
  • 6Gaynon PS, Angiolillo AL, Carroll WL, et al. Long - term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983 - 2002 : A Children's Oneology Group Report[ J]. Leuke- mht,2010,24(2) :285 -297.
  • 7Schultz KR, Jeanette PD, Sather HN, et al. Risk - and response - based classification of childhood B - precursor acute lymphoblastic leu- kemia: A combined analysis of prognostic markers from the Pediatric On- cology Group (POG) and Children' s Cancer Group (CCG) [ J ]. Blood, 2007,3(109) :926 -935.
  • 8Withycombe JS, Post - White JE, Meza JL, et al. Weight patterns in children with higher risk ALL: A report from the Children's Oncology Group (COG) for CCG 1961 [ J]. Pediatr Blood Cancer, 2009,53 ( 7 ) : 1249 - 1254.
  • 9Aricb M, Schrappe M, Hunger SP, et al. Clinical outcome of children with newly diagnosed Philadelphia chromosome - positive acute lympho- blastic leukemia treated between 1995 and 2005 [ J]. J Clin Oncol, 2010,28(31 ) :4755 -4761.
  • 10Escherich G, Troger A, Gobel U, et al. The long - term impact of in vitro drug sensitivity on risk stratification and treatment outcome in acute lymphoblastic leukemia of childhood ( CoALL 06 - 97 ) [ J ]. Haemato- Iogica, 2011,96 ( 6 ) : 854 - 862.

共引文献23

同被引文献29

引证文献3

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部