重组人干扰素α-2b凝胶联合CO_2激光治疗女性尖锐湿疣的临床观察

Clinical Efficacy of Recombinant Human Interferon α-2b Gel plus CO_2 Laser for Female Condyloma Acuminatum

目的:探讨重组人干扰素α-2b凝胶联合CO2激光治疗女性尖锐湿疣的临床疗效。方法:将112例女性尖锐湿疣患者,以随机数字表法分为治疗组与对照组各56例,治疗组患者给予重组人干扰素α-2b凝胶联合CO2激光治疗,对照组给予CO2激光治疗,观察2组患者连续治疗6个月的疗效。结果:治疗组总有效率为91.07%(51/56),3个月时的复发率为3.57%(2/56),6个月时的复发率为零;对照组总有效率为73.21%(41/56),3个月时的复发率为8.93%(5/56),6个月时的复发率3.57%(2/56)。治疗组的临床疗效明显优于对照组,2组差异有统计学意义(P<0.05)。结论:重组人干扰素α-2b凝胶联合CO2激光治疗女性尖锐湿疣,可提高治愈率、降低复发率,值得临床推广应用。

OBJECTIVE：To evaluate the clinical efficacy of recombinant human interferonα-2b gel plus CO2 laser for female condyloma acuminatum. METHODS：112 patients with female condyloma acuminatum were randomly divided into treatment group and control group（ each group was 56 cases） . The treatment group was treated with recombinant human interferon α-2b gel plus CO2 laser while the control group with CO2 laser alone. The therapeutic efficacy was followed for 6 consecutive months. RESULTS： The treatment group had total effective rate of 91-07%（ 51/56 ） , 3-month recurrence rate of 3.57%（ 2/56 ） and 6-month recurrence rate of 0 , as compared with total effective rate of 73.21%（41/56）, 3-month recurrence rate of 8-93%（5/56） and 6-month recurrence rate of 3-57%（2/56） in the control group, showing significantly better efficacy in the treatment group than in the control group （ P 〈0.05 ） . CONCLUSIONS：As compared with CO2 laser alone, treatment of female condyloma acuminatum with recombinant human interferonα-2b gel plus CO2 laser resulted in improved curative rate and reduced recurrence rate, which thus is worthy of popularization in clinical application.