2013年381例药品不良反应报告分析

Adverse Drug Reaction Reports in 2013: Analysis of 381 Cases

目的：了解陕西榆林市第一医院（以下简称“我院”）药品不良反应（ ADR）发生的特点和规律，以期减少ADR的发生，促进合理用药。方法：采用回归性分析法对2013年我院药剂科临床药学室收集的381份ADR报告进行统计分析、评价。结果：381例ADR报告中，发生ADR的男性患者（201例，占52.76％）多于女性患者（180例，占47.24％）；51～70岁的中老年患者（240例，占62.99％）多于其他年龄段患者；住院患者（348例，占91.34％）多于门诊患者（33例，占8.66％）；引发ADR的药物以抗感染药为主（173例，占45.41％）；给药途径以静脉滴注为主（327例，占85.83％）；ADR 的主要临床表现为皮肤及其附件损害（156例，占40.94％）；ADR报告类型多为一般的ADR（342例，占89.76％），结果多表现为痊愈（303例，占79.53％），发生的因果关系多为“很可能”（171例，占44.88％）。结论：ADR的发生与临床密切相关，医院应予以重视，加强对ADR的监测和上报工作，促进临床合理用药。

OBJECTIVE： To investigate the characteristics and regularity of the adverse drug reactions （ ADRs） occurred in Shaanxi Yulin First Municipal Hospital （ hereinafter referred to as “our hospital”） so as to reduce the incidence of ADR and promote rational use of drugs. METHODS：A total of 381 ADR case reports collected by clinical pharmacy room of pharmacy department of our hospital in 2013 were statistically analyzed and evaluated using regression analysis. RESULTS：Of the 381 ADR cases, males showed high proportion than females [（52.76%（201 cases） vs. 47.24%（ 180 cases ） ]; the patients aged 51.70 years took the lead with 240 cases （ 62.99%）; the inpatients outnumbered the outpatients [ 348 （ 91.34%） vs. 33 （ 8.66%） ];173 cases （ 45.41%） were induced by anti.infective drugs,327 cases（85.83%） by intravenous drip infusion;156 cases（40.94%） manifested as lesions of skin and its appendages. 342（89.76%） were common ADRs;303（79.53%） were cured;171 cases（44.88%） were considered as “most probably” in cause.effect relationship. CONCLUSIONS： The occurrence of ADR is closely associated with clinic;it is important for hospital to attach great importance to the ADR monitoring and reporting so as to promote clinical rational use of drugs.