摘要
目的观察慢性乙型肝炎肝纤维化患者慢肝0号方治疗前后临床症状、体征、肝功能、血清肝纤维化指标的变化。方法治疗组27例患者服用自拟"慢肝0号方",剂量为1.5g/次,3次/d;对照组25例只给予常规护肝治疗。两组疗程均为52周。结果慢肝0号方可有效改善慢性乙型肝炎患者的临床症状与体征;恢复肝功能,其效果与具明确保肝降酶作用的药物相同。慢肝0号方具有明显抗肝纤维化作用,治疗组治疗后血清透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(Pc-Ⅲ)、Ⅳ型胶原(Ⅳ-C)较治疗前明显下降,两组比较有明显差异。结论慢肝0号方除有明确保肝作用外,还有一定的抗肝纤维化作用。
Objective To observe the liver fibrosis of chronic hepatitis B patients with liver Mangan 0 Decoction before and after treatment of clinical symptoms, signs, the changes of liver function, serum liver fibrosis indexes. Methods The treatment group and 27 patients to take the Mangan 0 Decoction, the dose of 1.5 g/time, 3 times/d; 25 cases were only given routine protect liver treatment.Two groups of a course of 52 weeks. Results The Mangan 0 Decoction can effectively improve the clinical symptoms and signs of patients with chronic hepatitis B; To restore liver function, its effect and has the effects of clear liver enzyme reduction at the same drug. Mangan 0 Decoction party has obvious anti liver fibrosis, the treatment group after treatment, serum hyaluronic acid (HA) , layer adhesion protein (LN) , type Ⅲ before collagen (Pc-Ⅲ) , collagen type Ⅳ (Ⅳ-C) was decreased obviously, the two groups have obvious difference. Conclu- sion Mangan 0 Decoction has clear hepatoprotective effect, unless there is a certain anti hepatic fibrosis effect.
出处
《中国中医药现代远程教育》
2014年第23期25-26,共2页
Chinese Medicine Modern Distance Education of China
基金
江苏省中医药局科技项目[No:LB09108]
苏州市科技局科技计划项目[No:200903006]
关键词
慢性乙型肝炎
肝纤维化
慢肝0号方
chronic hepatitis B
liver fibrosis
Mangan 0 Decoction