柞蚕害虫螽斯防控颗粒饵剂中的赋形剂筛选

Screening of Excipients for Preparing Tablet Bait to Protect Antherae pernyi from Katydids

赋形剂是药物制剂的主要助剂之一。在用杀虫剂乙酰甲胺磷制备防控柞蚕害虫螽斯的颗粒饵剂配方中,以马铃薯粉为营养成分,分别以山梨糖醇、琼脂和蜂蜡作为赋形剂,通过测定颗粒饵剂的成形性能和保水性能等指标,筛选蜂蜡为最佳赋形剂。进一步考察颗粒饵剂的物料收率、堆码性能、保水性能、耐水性能和螽斯平均取食量等指标,优化赋形剂蜂蜡的用量,当蜂蜡与其他辅料(马铃薯粉等)的质量比为0.4时,颗粒饵剂的物料收率达到最大值,堆码及保水、耐水性能好,螽斯的取食量也较高。以蜂蜡为赋形剂并按优化的配比制备的颗粒铒剂,有利于保持乙酰甲胺磷对螽斯的杀灭效果。

Excipient is one of the main additives in pharmaceutical formulation. In the preparation of tablet bait formulations using pesticide acephate for protection of tussah silkworm（ Antheraea pernyi） against katydid,potato powder was used as nutrient material and sorbitol,agar and beeswax were used as excipient. Through measuring shape-forming ability,water retention capability and other properties of the prepared tablet bait,beeswax was found to be the best excipient. Furthermore,the dosage of excipient was optimized by taking into account the bait yield,stacking performance,water retention capability,anti-water erosion performance and average intake by katydids. When the mass ratio of beeswax to other ingredients（ potato powder etc） was 0. 4,the prepared bait had the maximum bait yield,excellent stacking,high water retention,anti-water erosion performance,and high intake amount by katydids. Therefore,the tablet bait prepared by using beeswax as excipient according to optimized formula is favorable for maintaining the toxicity of acephate against katydids.