血清尿酸和高敏C反应蛋白水平与非瓣膜性心房颤动患者血栓栓塞事件的相关性分析

Association of serum uric acid and high-sensitivity C-reactive protein with thromboembolic events in patients with nonvalvular atrial fibrillation

目的：探讨血清尿酸和高敏C反应蛋白（hs- CRP）水平与非瓣膜性心房颤动（NVAF）患者血栓栓塞事件的关系。方法回顾分析462例NVAF住院患者，按有无血栓栓塞事件分为栓塞组（n=63）和无栓塞组（n=399），比较组间的危险因素，分析血清尿酸水平与血栓栓塞事件的关系。结果栓塞组患者高血压、糖尿病、冠心病、心功能不全、高龄≥75岁者占比，血尿酸、hs- CRP、纤维蛋白原水平均高于无栓塞组，左心室射血分数（LVEF）低于无栓塞组，差异均有统计学意义（均P＜0.05）。血清尿酸水平与hs- CRP呈显著正相关（r=0.787，P＜0.01）。多因素logistic逐步回归分析显示血清尿酸水平升高是NVAF患者出现血栓栓塞事件的独立危险因子（OR1.05，95%CI1.02-1.17，P＜0.05）。结论血清尿酸升高与NVAF患者血栓栓塞事件存在一定相关性。

Objective To investigate the association of serum uric acid and high- sensitivity C- reactive protein （hs- CRP） with thromboembolic events in patients with nonvalvular atrial fibril ation （NVAF）. Methods 462 in- patients with NVAF were retrospectively analyzed and divided into embolism （n=63） and non- embolism （n=399） group based on with or without thromboembolic events. The risk factors for thromboembolism were compared between two groups. The relationship between serum uric acid and thromboembolic events was analyzed. Results Hypertension, diabetes, coronary heart disease, cardiac dysfunction, and people with age≥75 years were seen more frequently, serum uric acid, hs- CRP and fibrinogen were significantly higher, while left ventricular ejection fraction was significantly lower in embolism group than in non- embolism group（P〈0.05）. There was significant correlation between serum uric acid and hs- CRP（r=0.787, P〈0.01）. Multivariate logistic regression analysis showed that increased uric acid was an independent risk factor for thromboembolic events in patients with NVA （OR1.05, 95%CI1.02- 1.17, P〈0.05）. Conclusion Elevated uric acid is associated with thromboembolic events in patients with NVAF.