支气管镜检查对老年患者呼出气一氧化氮的影响

The influence of bronchoscopy on exhaled nitric oxide in elderly patients

目的 评估支气管镜检查对老年患者呼出气一氧化氮浓度（exhaled nitric oxide,FeNO）的影响.方法 2013年1月-2013年12月在上海交通大学医学院附属仁济医院呼吸科住院诊治的接受支气管镜检查的老年患者55例,其中男性32例,女性23例,平均（68.8±8.1）岁,分别于支气管镜检查前,检查后1、2、3和24h测定FeNO值.结果 支气管镜检查前FeNO的平均值为（21.7±3.1） ppb.在支气管镜检查后1h时FeNO显著减少到（14.8±2.1）ppb,P＜0.01.FeNO在2h时达到其最低点（14.2±2.3）ppb,P＜0.01.在24 h时,FeNO值为（22.4±2.9） ppb,P=0.73,与支气管镜检查前无明显差异.结论 目前导致FeNO短暂的下降,但机制目前仍不清楚.原因可能与利多卡因的使用和过度通气及咳嗽有关.

Objective To study the influence of bronchoscopy on fractional concentration of exhaled nitric oxide in elderlypatients. Methods Fifty fivesubjects （23F, 32M）, at meanage （68.8±8.1）years old, undergoing diagnostic bronchoscopy participated in the study. FeNO was analyzed before and at 1, 2, 3 and 24 h after bronchoscopy. Results The mean FeNO before bronchoscopy was （21.7±3.1） ppb, it decreased to （14.8 ±2.1） ppb 1 h after bronchoscopy, reached a nadir at 2 h （14.2±2.3 ） ppb, P〈0.01）, and was not different from baseline 24 h after bronchoscopy （22.8±2.90） ppb, P=0.73. Conclusions The mechanisms are at present unclear. Maybe related to use lidocaine or hyperventilation and coughing.