尿微量蛋白四项联检对非糖尿病高血压肾损伤的早期诊断价值

Value of the Combination Detection of Four Urine Micro-proteins in Early Diagnosis of Non-diabet- ic Hypertensive Renal Damage

目的 探讨尿微量蛋白中尿微量白蛋白（mAlb）、尿转铁蛋白（TRF）、尿α1微球蛋白（α1‐MG）、尿免疫球蛋白（Ig G ）四项联检对非糖尿病高血压肾损伤早期诊断价值。方法 通过分别对确诊非糖尿病高血压100例患者（观察组）和100例健康体检者（对照组）尿液进行尿微量蛋白四项进行检测，血液进行生化检测，并对检测结果进行统计学分析。结果 观察组尿微量蛋白高于对照组，mAlb阳性为35例（35％），TRF阳性为24例（24％），α1‐M G阳性为32例（32％），IgG阳性为15例（15％），四项联合检测的阳性率为55％，观察组高血压、肥胖、高C反应蛋白，低高密度脂蛋白与尿微量蛋白有相关性。结论 mAlb、TRF、α1‐MG、IgG联检能提高非糖尿病高血压肾损伤的早期诊断率。

Objective] To explore the value of the combination detection of four urine micro‐proteins urine trace albumin（mAlb） ,urinary transferrin（TRF） ,urine alpha 1 microglobulin（α1‐MG） and urine immunoglobulin （IgG） in early diagnosis of non‐diabetic hypertensive renal injury .[Methods]Four urine micro‐proteins of 100 pa‐tients confirmed as non‐diabetic hypertension（observation group） and 100 healthy physical examination persons （control group） were examined .Blood biochemical indicators were detected .The test results were analyzed statis‐tically .[Results] Urine micro‐proteins in observation group were higher than those in control group .The mAlb in 35 patients（35% ） ,TRF in 24 patients（24% ） ,α1‐MG in 32 patients（32% ） and IgG in 15 patients（15% ） were positive .The positive rate of the combination detection of four micro‐proteins was 55% .Hypertension ,obesity , high CRP ,low and high‐density lipoproteins in observation group had correlation with urine micro‐proteins .[Con‐clusion] The combination detection of mAlb ,TRF ,α1‐MG and IgG can improve early diagnostic rate of non‐dia‐betic hypertensive renal injury .