特比萘芬与伊曲康唑治疗甲真菌病疗效的Meta分析

Meta-analysis on terbinafine and itraconazole for onychomycosis

目的利用Meta分析评价特比萘芬与伊曲康唑治疗甲真菌病的疗效。方法 检索Cochrane图书馆、Pubmed数据库、中国生物医学文献数据库、CNKI数据库、VIP数据库、万方数据库等,纳入特比萘芬与伊曲康唑对比治疗甲真菌病的随机对照试验(RCT),进行方法学质量评价,并采用RevMan5.2软件进行统计分析。结果 8篇RCT文献纳入本项研究,累计病例1 208例。Meta分析结果显示,特比萘芬对提高痊愈率[OR1.97;95%CI(1.27,3.07),P<0.01]具有明显差异,而在有效率[OR 1.32;95%CI(0.86,2.03),P>0.05]和不良反应[OR 1.01;95%CI(0.76,1.33),P>0.05]方面则无明显差异。结论 特比萘芬在治疗甲真菌病中疗效确切,是治疗甲真菌病的有效方法。

Objective To evaluate the efficacy and safety of terbinafine versus itraconazole for onychomycosis through meat-analysis.Methods The studies involving randomized controlled trials（RCTs） were collected from the database,including Cochrane Library,Pubmed,CBMdisc,CNKI,VIP database and Wangfang database from the year of database creation to January 2014.After evaluation of the methodology on the studies included,the statistics was conducted using software RevMan5.2.Results Eight RCTs were eligibly identified,which included 1 208 cases.Meta-analysis showed that terbinafine in the treatment of onychomycosis had led to higher cure rate（OR=1.97;95%CI：1.27,3.07,P0.01）,yet the effective rate（OR=1.32;95%CI：0.86,2.03,P0.05） and adverse effects（OR=1.01;95%CI：0.76,1.33,P0.05） remained no significance as compared with itraconazole.Conclusion Terbinafine can be effective in treatment of onychomycosis.