肿瘤坏死因子α诱导核转录因子κB信号通路在特发性肺纤维化中的作用机制

Role of nuclear factor kappa B signaling pathway mediated by tumor necrosis factor-α in idiopathic pulmonary fibrosis

特发性肺纤维化（idiopathic pulmonary fibrosis,IPF）是一种由多种原因导致的、以弥漫性肺泡炎和肺泡结构紊乱、最终导致肺间质纤维化为特征的疾病.肿瘤坏死因子α（TNF-α）是一种细胞毒性因子,在肺纤维化的发病中起着关键作用.核转录因子κB（NF-κB）是一种多功能的核转录因子,近来研究表明,TNF-α可以通过激活NF-κB信号通路,参与肺纤维化的发生、发展.现对TNF-α介导NF-κB信号通路在IPF中的作用作一综述.

Idiopathic pulmonary fibrosis is a kind of disease which caused by a variety of reasons,characterized by diffuse alveolar inflammation and alveolar interstitial structure disorder,and finally evolved into chronic interstitial lung diseases.Tumor necrosis factor-α（TNF-α） is a cytotoxic factor,playing an important role in the pathogenesis of pulmonary fibrosis.Nuclear factor kappa B （NF-κB） has a variety of functions.Recent studies show that TNF-α plays a role in activating NF-κB signaling pathway in pulmonary fibrosis.This article reviews the mechanism of NF-κB signaling pathway mediated by TNF-α in idopathic pulmonary fibrosis.