卡前列素氨丁三醇联合卡前列甲酯栓治疗产后出血的效果和护理

Effect and nursing of Carboprost Tromethamine joint Carboprost Methylate Suppositorites in the treatment of postpartum hemorrhage

目的 探讨卡前列素氨丁三醇联合卡前列甲酯栓治疗产后出血的效果和护理。方法 选择2013年8月~2014年9月于瑞安市人民医院分娩发生难治性子宫收缩乏力性产后出血患者200例,依据产妇住院先后顺序随机分为治疗组和对照组,每组各100例。对照组常规肌内注射缩宫素20 U,静滴缩宫素20 U,口服米索前列醇片0.4 mg,并给予常规辅助治疗;治疗组口服卡前列甲酯栓1 mg,然后加深部肌内注射卡前列素氨丁三醇250μg,辅助治疗同对照组。产后均进行一般护理。比较两组患者产后出血情况、疗效与不良反应发生率。结果 两组患者的显效率及总有效率比较,治疗组明显好于对照组,差异均有高度统计学意义（P〈0.01）;治疗组产后出血量明显少于对照组,治疗组的平均出血量为（801.2±198.6）m L,对照组为（1213.2±231.6）m L,差异有高度统计学意义（P〈0.01）;治疗组出现恶心、呕吐、腹泻、发热、血压升高、寒战发生率明显低于对照组,差异有高度统计学意义（P〈0.01）。结论 卡前列素氨丁三醇联合卡前列甲酯栓治疗产后出血效果确切,能明显减少平均出血量,降低不良反应发生率,值得临床推广使用。

Objective To discuss effect and nursing of Carboprost Tromethamine joint Carboprost Methylate Suppositorites treat postpartum hemorrhage. Methods 200 cases of puerperas with postpartum hemorrhage because of refractory uterine contractions fatigue from August 2013 to September 2014 in the People＇s Hospital of Rui＇an City were selected,they were randomly divided into treatment group and control group on the basis of admitting time 100 cases in each group. Patients of the control group were given routine intramuscular injection 20 U oxytocin, the static drop 20 U oxytocin, oral misoprostol tablets 0.4 mg, and conventional adjuvant therapy; the treatment group was given oral Carboprost Methylate Suppositorites 1 mg, then injected Carboprost Tromethamine 250 μg in deep of the uterus, adjuvant treatment was same with the control group. All puerperas were given the general care postpartum. The postpartum bleeding,efficacy and incidence of adverse reactions of patients in the two groups were compared. Results Patients of two groups with significant efficiency and total effective rate, treatment group was significantly better than the control group, the differences were statistically significant（P〈0.01）; Postpartum haemorrhage amount significantly lower in the treatment group than the control group, the average blood loss of treatment group was（801.2±198.6） m L, the control group was（1213.2±231.6） m L, the difference was statistically significant（P〈0.01）; The incidence of adverse reactions such as nausea, vomiting, diarrhea, fever, high blood pressure, and chills of the treatment group were obviously lower than those of the control group, the differences were statistically significant（P〈0.01）. Conclusion Carboprost Tromethamine joint Carboprost Methylate Suppositorites treat postpartum hemorrhage curative effect definite, it can obviously reduce the average blood loss and the incidence of adverse reactions, worthy of clinical promotion.