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MicroRNA在突触可塑性中的作用

Roles of MicroRNA in synaptic plasticity
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摘要 microRNA(miRNA)是一种内源性的,长度约为22 nt的非编码小分子RNA,对基因的转录后调控具有重要作用。miRNA在脑中大量表达,对神经元的生长发育起关键作用,同时miRNA还参与神经功能的实施,如突触可塑性。本文将重点讨论miRNA对神经突触可塑性的调节作用。 micro RNAs（mi RNA） are small endogenous non-coding RNAs of approximately 22 nucleotides that play a crucial role in the post-transcriptional gene regulation. mi RNAs are enriched in the brain, where they can contribute significantly to the development, survival of neurons, meanwhile they might be important mediators of neural functions,such as synaptic plasticity. This review discusses the regulation of mi RNAs in synaptic plasticity.
作者 胡雪玲 孙丽华
机构地区 哈尔滨医科大学药学院
出处 《中国医药导报》 CAS 2014年第36期153-158,共6页 China Medical Herald
基金 国家自然科学基金面上项目(编号81371211)
关键词 MIRNA 神经系统 突触可塑性 学习和记忆 miRNA Nervous system Synaptic plasticity Learning and memory
分类号 R741 [医药卫生—神经病学与精神病学]
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中国医药导报
2014年 第36期

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